Evidence map›Paper›PMID 39688164›Full record

ArticleMaternal & child nutrition2025

Impact of Early Life Famine Exposure on Body Composition and Metabolic Profiles in Adulthood.

Shuaihua Song, Liyuan Zhang, Hanze Du, Yuelun Zhang, Yue Jiang, Daowei Li, Yi Hu, Shi Chen, Huijuan Zhu, Guangliang Shan and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Maternal & child nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Shuaihua SongKey Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China.
Liyuan ZhangKey Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China.
Hanze DuKey Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China.
Yuelun ZhangCenter for Prevention and Early Intervention, National Infrastructures for Translational Medicine, Institute of Clinical Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.
Yue JiangKey Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China.
Daowei LiJilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, School and Hospital of Stomatology, Jilin University, Changchun, China.
Yi HuState Key Laboratory of Complex, Severe, and Rare Diseases, Biomedical Engineering Facility of National Infrastructures for Translational Medicine, Peking Union Medical College Hospital, Beijing, China.
Shi ChenKey Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China.
Huijuan ZhuKey Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China.
Guangliang ShanDepartment of Epidemiology and Statistics, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & School of Basic Medicine, Peking Union Medical College, Beijing, China.
Hui PanKey Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China.ORCID 0000-0003-2413-0646

Funding

CAMS Innovation Fund for Medical Sciences 2021-I2M-1-023
6 · The paper itself

Abstract

The relationship between the famine and metabolic syndrome has been reported, but there is a lack of more detailed changes in metabolic profiles. It is unclear how famine affects body composition. This study included 21,142 participants from the China National Health Survey. The body mass index (BMI), fat mass index (FMI), and fat-free mass index (FFMI) were calculated. Systolic blood pressure (SBP), diastolic blood pressure (DBP), blood lipids, and fasting blood glucose (FBG) were measured. Multivariate adjusted linear regression models were used to assess the association between famine and outcome. Our results shown that fetal-exposed group had higher BMI and FMI (β > 0). Childhood-exposed group showed an average decrease of 0.08 standard deviation (SD) in FFMI, and adolescence-exposed group had lower BMI and FFMI than non-exposed group. SBP were 0.38 SD higher in fetal-exposed group, 0.58 SD higher in childhood-exposed group and 0.85 SD higher in adolescence-exposed group than non-exposed group. Famine-exposed groups had higher total cholesterol (TC), low density lipoprotein-cholesterol (LDL-C), and FBG levels (β > 0). For females with famine exposure, they had a higher BMI, FMI, LDL-C, TG, and TC than males. Overall, early famine exposure is associated with increased blood pressure, LDL-C, TC, and FBG. Muscle mass loss in adulthood associated with childhood and adolescence famine exposure. Famine-exposed females appear to have higher levels of body fat and blood lipids.

Indexed as

Body CompositionFamineMetabolomeAdolescentAdultBlood GlucoseBlood PressureBody Mass IndexChildChinaFemaleHumansLipidsMaleMetabolic SyndromeMiddle AgedBlood GlucoseLipidsadulthoodbody compositionfaminemalnutritionmetabolic profiles

Identifiers

PMID39688164
PMCPMC11956060

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.