Evidence map›Paper›PMID 39687626›Full record

ArticleFrontiers in immunology2024

Kir6.1, a component of an ATP-sensitive potassium channel, regulates natural killer cell development.

Natalie Samper, Lilja Hardardottir, Delphine M Depierreux, Soomin C Song, Ayano Nakazawa, Ivan Gando, Tomoe Y Nakamura, Andrew M Sharkey, Carla R Nowosad, Stefan Feske and 2 more

Abstract read
In one paragraph

Article in Frontiers in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Natalie Samper *Department of Pathology, NYU Grossman School of Medicine, New York, NY, United States.
Lilja Hardardottir *Department of Obstetrics and Gynecology, University of Cambridge, Cambridge, United Kingdom.
Delphine M Depierreux *Department of Obstetrics and Gynecology, University of Cambridge, Cambridge, United Kingdom.
Soomin C SongDepartment of Pathology, NYU Grossman School of Medicine, New York, NY, United States.
Ayano NakazawaDepartment of Pharmacology, Wakayama Medical University, Wakayama, Japan.
Ivan GandoDepartment of Pathology, NYU Grossman School of Medicine, New York, NY, United States.
Tomoe Y NakamuraDepartment of Pharmacology, Wakayama Medical University, Wakayama, Japan.
Andrew M SharkeyDepartment of Pathology, University of Cambridge, Cambridge, United Kingdom.
Carla R NowosadDepartment of Pathology, NYU Grossman School of Medicine, New York, NY, United States.
Stefan FeskeDepartment of Pathology, NYU Grossman School of Medicine, New York, NY, United States.
Francesco ColucciDepartment of Obstetrics and Gynecology, University of Cambridge, Cambridge, United Kingdom.
William A CoetzeeDepartment of Pathology, NYU Grossman School of Medicine, New York, NY, United States.

Funding

Vaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI MARK Reid PHILIPS · 1985 to 2026
$83.1M
CRAC Channel Deficiency in Immunity to InfectionR01AI097302 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI FESKE, STEFAN · 2012 to 2022
$5.6M
Roles of Endothelial and Smooth Muscle KATP Channels in Myocardial Ischemic InjuryR01HL146514 · NHLBI · LSU HEALTH SCIENCES CENTER · PI COETZEE, WILLIAM A, LEFER, DAVID JOSEPH · 2020 to 2023
$3.0M
Functional interaction between cardiac Na channels and KATP channelsR01HL148609 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI COETZEE, WILLIAM A, DELMAR, MARIO · 2020 to 2023
$2.7M
Ca2+ signaling via SOCE in the pathogenesis of Sjögren’s syndromeR01DE027981 · NIDCR · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI FESKE, STEFAN, LACRUZ, RODRIGO S. · 2019 to 2023
$2.7M
Regulation of Follicular T cell Responses in the Lung by Ion ChannelsR01AI130143 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI FESKE, STEFAN · 2017 to 2021
$2.4M
Conditional knockout mice lacking K(ATP) channel subunitsR21HL093563 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI COETZEE, WILLIAM A · 2009 to 2010
$465k
Multispectral imaging & analysis of intact tissue sections w/ the Perkin Elmer VectraS10OD021747 · OD · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI LOOMIS, CYNTHIA A · 2016 to 2016
$359k
FAM26F function and role in macrophagesR03TR004157 · NCATS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI COETZEE, WILLIAM A, FESKE, STEFAN · 2022 to 2022
$170k
Tweety proteins: their roles in pericytes and macrophagesR03TR004459 · NCATS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI COETZEE, WILLIAM A, FESKE, STEFAN · 2023 to 2023
$170k
NCATS NIH HHS R03 TR004157NCATS NIH HHS R03 TR004459NCI NIH HHS P30 CA016087NHLBI NIH HHS R01 HL146514NHLBI NIH HHS R01 HL148609NHLBI NIH HHS R21 HL093563NIAID NIH HHS R01 AI097302NIAID NIH HHS R01 AI130143NIDCR NIH HHS R01 DE027981NIH HHS S10 OD021747Wellcome Trust
6 · The paper itself

Abstract

Introduction: Involved in immunity and reproduction, natural killer (NK) cells offer opportunities to develop new immunotherapies to treat infections and cancer or to alleviate pregnancy complications. Most current strategies use cytokines or antibodies to enhance NK-cell function, but none use ion channel modulators, which are widely used in clinical practice to treat hypertension, diabetes, epilepsy, and other conditions. Little is known about ion channels in NK cells. Results: We show that Discussion: These results show that the K

Indexed as

KATP ChannelsKiller Cells, NaturalAnimalsCell DifferentiationFemaleMiceMice, Inbred C57BLMice, KnockoutSpleenUterusKATP ChannelsuK-ATP-1 potassium channelATP-sensitive potassium channelsinnate immunityion channelsNK cell developmentNK cellspotassium channels

Identifiers

PMID39687626
PMCPMC11646858

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.