Evidence map›Paper›PMID 39687546›Full record

Observational studyFrontiers in cellular and infection microbiology2024

Pneumococcal carriage in a large Sicilian sample population: impact on the current epidemiological scenario and implications for future vaccination strategies.

Emanuele Amodio, Fabio Tramuto, Valerio De Francisci, Dario Genovese, Valeria Guzzetta, Vincenzo Pisciotta, Arianna Santino, Giulia Randazzo, Giulio Trapani, Giuseppe Vella and 1 more

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Frontiers in cellular and infection microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Digital PCR linkage analysis resolvesMicrobiology spectrum · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Emanuele Amodio *Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties "P. Giaccone", University of Palermo, Palermo, Italy.
Fabio Tramuto *Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties "P. Giaccone", University of Palermo, Palermo, Italy.
Valerio De FrancisciDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties "P. Giaccone", University of Palermo, Palermo, Italy.
Dario GenoveseDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties "P. Giaccone", University of Palermo, Palermo, Italy.
Valeria GuzzettaRegional Reference Laboratory for Molecular Surveillance of Influenza, Clinical Epidemiology Unit, University Hospital "Paolo Giaccone", Palermo, Italy.
Vincenzo PisciottaDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties "P. Giaccone", University of Palermo, Palermo, Italy.
Arianna SantinoRegional Reference Laboratory for Molecular Surveillance of Influenza, Clinical Epidemiology Unit, University Hospital "Paolo Giaccone", Palermo, Italy.
Giulia RandazzoRegional Reference Laboratory for Molecular Surveillance of Influenza, Clinical Epidemiology Unit, University Hospital "Paolo Giaccone", Palermo, Italy.
Giulio TrapaniDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties "P. Giaccone", University of Palermo, Palermo, Italy.
Giuseppe VellaDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties "P. Giaccone", University of Palermo, Palermo, Italy.
Francesco VitaleDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties "P. Giaccone", University of Palermo, Palermo, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Methods: Observational study randomly selecting samples belonging to Sicilian individuals whose nasopharyngeal swabs were collected between February 1, 2020, and December 31, 2022. Pneumococcal colonization was determined using PCR for the pneumococcal autolysin (LytA) gene, and positive samples were serotyped. Results: The study sample consisted of 1,196 individuals, with 17.4% testing positive for the LytA gene. Pneumococcal colonization rates fell from birth to 24 years, with a peak in 0-4-year-olds (aOR=6.9; p<0.001). Colonization was higher in colder months, particularly in December (aOR=2.9, p<0.05) and February (aOR=4, p<0.05). Serotypes 22F and 24ABF exhibited strong colonization and an invasive pneumococcal disease (IPD) risk, whereas serotypes 4, 6AB, 9VA, and 13 had high colonization but a low IPD risk. Serotypes 3 and 8 exhibited considerable IPD risk but low colonization. Conclusion: Our findings provide insights into pneumococcal colonization mechanisms, influencing serotype prevalence, colonization risk variables, and serotype comparisons for colonization and pathogenicity propensity.

Indexed as

Carrier StateNasopharynxPneumococcal InfectionsSerogroupStreptococcus pneumoniaeAdolescentAdultAgedAged, 80 and overChildChild, PreschoolFemaleHumansInfantInfant, NewbornMaleN-Acetylmuramoyl-L-alanine AmidasePneumococcal VaccinescarriagecolonizationepidemiologyserotypesStreptococcus pneumoniae

Identifiers

PMID39687546
PMCPMC11647007

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.