Evidence map›Paper›PMID 39687429›Full record

ArticleEClinicalMedicine2024

A telerehabilitation program to improve visual perception in children and adolescents with hemianopia consecutive to a brain tumor: a single-arm feasibility and proof-of-concept trial.

Mariana Misawa, Inci Yaman Bajin, Bill Zhang, Monica Daibert-Nido, Danielle Tchao, Eduardo Garcia-Giler, Kyle Cheung, Lora Appel, Pi Nasir, Arun Reginald and 6 more

2 registry-linked trialsAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EClinicalMedicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05065268 nacompletednot on this map

Visual Rehabilitation in a Pediatric Population of Patients With Homonymous Hemianopia: a Pilot Study on Virtual-reality Stimulation

TypeinterventionalSponsorThe Hospital for Sick ChildrenRan2022 to 2023Enrolled10ConditionsHemianopia, Brain Tumor, Children, OnlyArmsImmersive Virtual-Reality Stimulation
NCT07112560 not yet recruitingnot on this mapstarted 2025, after this paper: background citation

Early Detection and Prevention of Amblyopia and Visual Impairment Through Systematic Pediatric Vision Screening

TypeobservationalSponsorUniversity Hospital, Strasbourg, FranceRan2025 to 2026Enrolled40ConditionsAmblyopiaArmsStandard screening procedure for amblyopia, New amblyopia screening method using a virtual reality headset.
3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Trial
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Mariana MisawaOphthalmology and Vision Science, University of Toronto, 27 King's College Cir, Toronto, ON, M5S1A1, Canada.
Inci Yaman BajinNeuro-Oncology, The Hospital for Sick Children, 170 Elizabeth St, Toronto, ON, M5G1E8, Canada.
Bill ZhangDonald K. Johnson Eye Institute, Krembil Research Institute, University Health Network, 60 Leonard Av, Toronto, ON, M5T0S8, Canada.
Monica Daibert-NidoOphthalmology and Vision Science, University of Toronto, 27 King's College Cir, Toronto, ON, M5S1A1, Canada.
Danielle TchaoOpenLab, University Health Network, 190 Elizabeth St, Toronto, ON, M5G 2C4, Canada.
Eduardo Garcia-GilerDonald K. Johnson Eye Institute, Krembil Research Institute, University Health Network, 60 Leonard Av, Toronto, ON, M5T0S8, Canada.
Kyle CheungDonald K. Johnson Eye Institute, Krembil Research Institute, University Health Network, 60 Leonard Av, Toronto, ON, M5T0S8, Canada.
Lora AppelOpenLab, University Health Network, 190 Elizabeth St, Toronto, ON, M5G 2C4, Canada.
Pi NasirDonald K. Johnson Eye Institute, Krembil Research Institute, University Health Network, 60 Leonard Av, Toronto, ON, M5T0S8, Canada.
Arun ReginaldOphthalmology and Vision Science, University of Toronto, 27 King's College Cir, Toronto, ON, M5S1A1, Canada.
Uri TaboriNeuro-Oncology, The Hospital for Sick Children, 170 Elizabeth St, Toronto, ON, M5G1E8, Canada.
Ute BartelsNeuro-Oncology, The Hospital for Sick Children, 170 Elizabeth St, Toronto, ON, M5G1E8, Canada.
Vijay RamaswamyNeuro-Oncology, The Hospital for Sick Children, 170 Elizabeth St, Toronto, ON, M5G1E8, Canada.
Samuel N MarkowitzOphthalmology and Vision Science, University of Toronto, 27 King's College Cir, Toronto, ON, M5S1A1, Canada.
Eric BouffetNeuro-Oncology, The Hospital for Sick Children, 170 Elizabeth St, Toronto, ON, M5G1E8, Canada.
Michael ReberOphthalmology and Vision Science, University of Toronto, 27 King's College Cir, Toronto, ON, M5S1A1, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Brain tumor in children can induce hemianopia, a loss of conscious vision, profoundly impacting their development and quality of life, yet no effective intervention exists for this pediatric population. This study aimed to explore the feasibility, safety, and potential effectiveness of a home-based audiovisual stimulation in immersive virtual-reality (3D-MOT-IVR) to improve visual function and functional vision. Methods: In a phase 2a, open-labeled, nonrandomized, single-arm study, conducted from July 2022 to October 2023 (NCT05065268), 10 children and adolescents with stable hemianopia were enrolled to perform 20-min sessions of 3D-MOT-IVR every other day for six weeks from home. We assessed feasibility by monitoring adoption, adherence and completion rates, remote data transfer and qualitative feedback. Safety was evaluated using validated cybersickness questionnaires. Comprehensive vision assessments following standardized low-vision evaluation procedures were conducted pre- and post-intervention, with follow-ups at 1- and 6 months. Findings: The home-based 3D-MOT-IVR intervention proved both feasible and safe, with no reported adverse events. All participants completed the prescribed stimulations and the pre- and post-intervention assessment points, 90% completed the follow-ups. Nine out of ten participants showed clinically meaningful enhancement in visual function and/or functional vision, namely binocular visual field restoration and increased reading speed, but two showed concomitant deterioration in monocular visual field. These positive effects were sustained at the 6-month follow-up. Exploratory outcomes revealed a significant positive correlation between the performance at the 3D-MOT-IVR intervention and the visual perception at the binocular visual field test. Interpretation: Our findings underscore the feasibility and safety of home-based audiovisual stimulation in immersive virtual-reality as a potential intervention for improving visual perception in children/adolescents with hemianopia consecutive to a pediatric brain tumor. These promising results lay a strong foundation for a larger randomized controlled trial, offering hope for a meaningful breakthrough in visual rehabilitation for this vulnerable population. Funding: Meagan Bebenek Foundation and University Health Network Foundation.

Indexed as

Audiovisual stimulationHemianopiaLow grade gliomasSupportive careVirtual-reality

Identifiers

PMID39687429
PMCPMC11646794

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.