Evidence map›Paper›PMID 39687422›Full record

ArticleCurrent research in food science2024

Verification of the interaction between human bitter taste receptor T2R46 and polyphenols; Computational chemistry approach.

Takafumi Shimizu, Taiki Fushimi, Rio Ohno, Fujii Yasuyuki, Kenta Aso, Ursula M Jacobs, Osamu Nureki, Yoshitomo Suhara, Vittorio Calabrese, Naomi Osakabe

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current research in food science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Takafumi ShimizuSystems Engineering and Science, Graduate School of Engineering and Science, Shibaura Institute of Technology, Japan.
Taiki FushimiFunctional Control Systems, Graduate School of Engineering and Science, Shibaura Institute of Technology, Japan.
Rio OhnoDepartment of Bioscience and Engineering, Faculty of System Science and Engineering, Shibaura Institute of Technology, Japan.
Fujii YasuyukiSIT Research Laboratories, Shibaura Institute of Technology, Japan.
Kenta AsoCentral Research Institute, ITO EN, Ltd., Japan.
Ursula M JacobsSystem Biologie AG, Wollerau, (CH), Switzerland.
Osamu NurekiDepartment of Biological Sciences, Graduate School of Science, The University of Tokyo, Japan.
Yoshitomo SuharaSystems Engineering and Science, Graduate School of Engineering and Science, Shibaura Institute of Technology, Japan.
Vittorio CalabreseDepartment of Biomedical and Biotechnological Sciences, University of Catania, Italy.
Naomi OsakabeSystems Engineering and Science, Graduate School of Engineering and Science, Shibaura Institute of Technology, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recent studies have indicated that the activation of bitter taste receptors (T2R) expressed in gastrointestinal secretory cells has a regulatory effect on the secretion of gastrointestinal hormones. Polyphenols are known to be ingested at a daily intake of 5 g or more and commonly have a bitter taste. Consequently, the interaction between the bitter taste receptor T2R46 and 490 polyphenols was investigated using

Indexed as

Molecular docking simulationPolyphenolQuantitative structure-activation relationshipT2R46

Identifiers

PMID39687422
PMCPMC11647170

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.