Evidence map›Paper›PMID 39687410›Full record

ArticleBiochemistry and biophysics reports2024

Computational docking of FtsZ: Survey of promising antibiotic compounds.

Ileini N Espino, Julia Drolet, Ty-Niquia Jones, Antonette Uwechue, Brittany Koehler, Raquel Beaird, Sanni Maione, Christine Darrah, Rana Hijazi, Christopher James and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemistry and biophysics reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Ileini N EspinoState University of New York at Plattsburgh, 101 Broad Street, Plattsburgh, 12901, NY, USA.
Julia DroletState University of New York at Plattsburgh, 101 Broad Street, Plattsburgh, 12901, NY, USA.
Ty-Niquia JonesState University of New York at Plattsburgh, 101 Broad Street, Plattsburgh, 12901, NY, USA.
Antonette UwechueState University of New York at Plattsburgh, 101 Broad Street, Plattsburgh, 12901, NY, USA.
Brittany KoehlerState University of New York at Plattsburgh, 101 Broad Street, Plattsburgh, 12901, NY, USA.
Raquel BeairdState University of New York at Plattsburgh, 101 Broad Street, Plattsburgh, 12901, NY, USA.
Sanni MaioneState University of New York at Plattsburgh, 101 Broad Street, Plattsburgh, 12901, NY, USA.
Christine DarrahState University of New York at Plattsburgh, 101 Broad Street, Plattsburgh, 12901, NY, USA.
Rana HijaziState University of New York at Plattsburgh, 101 Broad Street, Plattsburgh, 12901, NY, USA.
Christopher JamesState University of New York at Plattsburgh, 101 Broad Street, Plattsburgh, 12901, NY, USA.
Annabelle DupreState University of New York at Plattsburgh, 101 Broad Street, Plattsburgh, 12901, NY, USA.
Ewa KoscinskiState University of New York at Plattsburgh, 101 Broad Street, Plattsburgh, 12901, NY, USA.
Leilani CreftState University of New York at Plattsburgh, 101 Broad Street, Plattsburgh, 12901, NY, USA.
Michael GiampaoloState University of New York at Plattsburgh, 101 Broad Street, Plattsburgh, 12901, NY, USA.
Alexandre BernierState University of New York at Plattsburgh, 101 Broad Street, Plattsburgh, 12901, NY, USA.
Kelly E TheisenState University of New York at Plattsburgh, 101 Broad Street, Plattsburgh, 12901, NY, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The bacterial cell-division protein FtsZ has been a promising antibiotic target for over a decade now, but there is still a need for more work in this area. So far there are no FtsZ targeting drugs commercially available. We have analyzed a wide variety of prospective drugs and their interactions with multiple FtsZ species using both free and directed docking simulations. Our goal is to present a standardized computational screening method for potential drug compounds targeting FtsZ. Our work is an example of a way to compare many proposed drugs and FtsZ species combinations relatively quickly. A common method for comparison can yield new results that individual studies and varying methods might not show, as we demonstrate here. To our knowledge this is one of the first, if not the first, computational docking study on the new E. coli FtsZ structures obtained in 2020.

Indexed as

00001111AntibioticsFtsZMolecular docking

Identifiers

PMID39687410
PMCPMC11647940

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.