Evidence map›Paper›PMID 39687338›Full record

ArticleRSC advances2024

Electrophilic aromatic substitution using fluorinated isoxazolines at the C5 position

Kazuyuki Sato, Tomohiro Kuroki, Haruka Minami, Azusa Sato, Yukiko Karuo, Atsushi Tarui, Kentaro Kawai, Masaaki Omote

Abstract read
In one paragraph

Article in RSC advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kazuyuki SatoFaculty of Pharmaceutical Sciences, Setsunan University 45-1 Nagaotoge-cho Hirakata Osaka 573-0101 Japan sato@pharm.setsunan.ac.jp.ORCID https://orcid.org/0000-0001-6572-602X
Tomohiro KurokiFaculty of Pharmaceutical Sciences, Setsunan University 45-1 Nagaotoge-cho Hirakata Osaka 573-0101 Japan sato@pharm.setsunan.ac.jp.
Haruka MinamiFaculty of Pharmaceutical Sciences, Setsunan University 45-1 Nagaotoge-cho Hirakata Osaka 573-0101 Japan sato@pharm.setsunan.ac.jp.
Azusa SatoSchool of Pharmacy, Tokyo University of Pharmacy and Life Sciences 1432-1 Horinouchi Hachioji Tokyo 192-0392 Japan.
Yukiko KaruoFaculty of Pharmaceutical Sciences, Setsunan University 45-1 Nagaotoge-cho Hirakata Osaka 573-0101 Japan sato@pharm.setsunan.ac.jp.
Atsushi TaruiFaculty of Pharmaceutical Sciences, Setsunan University 45-1 Nagaotoge-cho Hirakata Osaka 573-0101 Japan sato@pharm.setsunan.ac.jp.
Kentaro KawaiFaculty of Pharmaceutical Sciences, Setsunan University 45-1 Nagaotoge-cho Hirakata Osaka 573-0101 Japan sato@pharm.setsunan.ac.jp.
Masaaki OmoteFaculty of Pharmaceutical Sciences, Setsunan University 45-1 Nagaotoge-cho Hirakata Osaka 573-0101 Japan sato@pharm.setsunan.ac.jp.ORCID https://orcid.org/0000-0003-1210-1768

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Electrophilic aromatic substitution at the C5 position of isoxazolines and construction of a new quaternary carbon center were achieved in this paper. This is the first report of carbon-carbon (C-C) bond formation onto isoxazoline without compromising the ring structure. Various aromatics including heteroaromatics gave the desired products in good yields, especially aromatics bearing electron-donating groups. The reaction proceeds

Identifiers

PMID39687338
PMCPMC11647199

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.