Integrated proteomic and transcriptomic landscape of human placenta in small for gestational age infants.

Heyue Jin, Xianyan Wang, Lingyu Li, Chen Rui, Hong Gan, Qunan Wang, Fangbiao Tao, Yumin Zhu

Abstract read

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Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Heyue JinDepartment of Maternal & Child and Adolescent Health, School of Public Health, MOE Key Laboratory of Population Health Across Life Cycle, Anhui Provincial Key Laboratory of Population Health and Aristogenics, Anhui Medical University, Hefei, Anhui 230032, China.

Xianyan WangDepartment of Toxicology, School of Public Health, Anhui Medical University, Hefei, Anhui 230032, China.

Lingyu LiDepartment of Toxicology, School of Public Health, Anhui Medical University, Hefei, Anhui 230032, China.

Chen RuiDepartment of Toxicology, School of Public Health, Anhui Medical University, Hefei, Anhui 230032, China.

Hong GanDepartment of Maternal & Child and Adolescent Health, School of Public Health, MOE Key Laboratory of Population Health Across Life Cycle, Anhui Provincial Key Laboratory of Population Health and Aristogenics, Anhui Medical University, Hefei, Anhui 230032, China.

Qunan WangDepartment of Toxicology, School of Public Health, Anhui Medical University, Hefei, Anhui 230032, China.

Fangbiao TaoDepartment of Maternal & Child and Adolescent Health, School of Public Health, MOE Key Laboratory of Population Health Across Life Cycle, Anhui Provincial Key Laboratory of Population Health and Aristogenics, Anhui Medical University, Hefei, Anhui 230032, China.

Yumin ZhuMedical School, Nanjing University, Nanjing, Jiangsu 210093, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Small for gestational age (SGA) infants affected by placental insufficiency are exposed to the risk of stillbirth and long-term complications. Based on RNA-seq and mass spectrometry, we identified dysregulated RNAs and proteins from the comparisons of SGA placental tissues and controls. We revealed two SGA-relevant co-expression modules (SRMs) that also significantly distinguished SGA from controls. Then we performed an integrated analysis of transcriptomic and proteomic profiles to trace their links to SGA as well as their significant correlations. For the core functional molecules we screened, we revealed their potential upstream regulators and validated them experimentally in an independent cohort. Overall, we pointed out insights into different molecular pathways for the pathological mechanisms of SGA and indicated potential target molecules that may be drivers of placental aberrations in the SGA infants.

Indexed as

Developmental anatomyPregnancyProteomicsTranscriptomics

Identifiers

PMID39687015

DOI10.1016/j.isci.2024.111423

PMCPMC11648249

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.