Evidence map›Paper›PMID 39686878›Full record

ArticleArchiv der Pharmazie2025

Conjugates of amiridine and salicylic derivatives as promising multifunctional CNS agents for potential treatment of Alzheimer's disease.

Galina F Makhaeva, Maria V Grishchenko, Nadezhda V Kovaleva, Natalia P Boltneva, Elena V Rudakova, Tatiana Y Astakhova, Elena N Timokhina, Pavel G Pronkin, Sofya V Lushchekina, Olga G Khudina and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Archiv der Pharmazie, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Galina F MakhaevaInstitute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, Chernogolovka, Russia.ORCID http://orcid.org/0000-0002-8136-6906
Maria V GrishchenkoPostovsky Institute of Organic Synthesis, Urals Branch of the Russian Academy of Sciences, Ekaterinburg, Russia.ORCID http://orcid.org/0000-0003-4110-2620
Nadezhda V KovalevaInstitute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, Chernogolovka, Russia.ORCID http://orcid.org/0000-0002-4990-5068
Natalia P BoltnevaInstitute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, Chernogolovka, Russia.ORCID http://orcid.org/0000-0002-7171-8832
Elena V RudakovaInstitute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, Chernogolovka, Russia.ORCID http://orcid.org/0000-0002-4600-7799
Tatiana Y AstakhovaInstitute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, Chernogolovka, Russia.ORCID http://orcid.org/0000-0002-3034-9698
Elena N TimokhinaEmanuel Institute of Biochemical Physics, Russian Academy of Sciences, Moscow, Russia.ORCID http://orcid.org/0000-0003-2953-1705
Pavel G PronkinInstitute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, Chernogolovka, Russia.ORCID http://orcid.org/0000-0003-1483-106X
Sofya V LushchekinaDepartment of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel.ORCID http://orcid.org/0000-0002-6922-020X
Olga G KhudinaPostovsky Institute of Organic Synthesis, Urals Branch of the Russian Academy of Sciences, Ekaterinburg, Russia.ORCID http://orcid.org/0000-0002-8390-3365
Ekaterina F ZhilinaPostovsky Institute of Organic Synthesis, Urals Branch of the Russian Academy of Sciences, Ekaterinburg, Russia.ORCID http://orcid.org/0000-0002-1657-440X
Evgeny V ShchegolkovPostovsky Institute of Organic Synthesis, Urals Branch of the Russian Academy of Sciences, Ekaterinburg, Russia.ORCID http://orcid.org/0000-0001-6611-2855
Maria A LapshinaInstitute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, Chernogolovka, Russia.ORCID http://orcid.org/0000-0002-5111-5241
Elena S DubrovskayaInstitute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, Chernogolovka, Russia.ORCID http://orcid.org/0009-0003-1300-3665
Eugene V RadchenkoInstitute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, Chernogolovka, Russia.ORCID http://orcid.org/0000-0002-2091-7022
Vladimir A PalyulinInstitute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, Chernogolovka, Russia.ORCID http://orcid.org/0000-0001-8792-8386
Yanina V BurgartPostovsky Institute of Organic Synthesis, Urals Branch of the Russian Academy of Sciences, Ekaterinburg, Russia.ORCID http://orcid.org/0000-0001-6061-2410
Victor I SaloutinPostovsky Institute of Organic Synthesis, Urals Branch of the Russian Academy of Sciences, Ekaterinburg, Russia.ORCID http://orcid.org/0000-0003-1976-7861
Valery N CharushinPostovsky Institute of Organic Synthesis, Urals Branch of the Russian Academy of Sciences, Ekaterinburg, Russia.ORCID http://orcid.org/0000-0002-9140-358X
Rudy J RichardsonDepartment of Environmental Health Sciences, University of Michigan, Ann Arbor, Michigan, USA.ORCID http://orcid.org/0000-0002-2028-5723

Funding

Russian Science Foundation Project No. 24-63-00016
6 · The paper itself

Abstract

New conjugates of amiridine and salicylic derivatives (salicylamide, salicylimine, and salicylamine) with different lengths of alkylene spacers were designed, synthesized, and evaluated as potential multifunctional central nervous system therapeutic agents for Alzheimer's disease (AD). Conjugates demonstrated high acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibition (IC

Indexed as

AcetylcholinesteraseAlzheimer DiseaseButyrylcholinesteraseCholinesterase InhibitorsAminoquinolinesAmyloid beta-PeptidesAntioxidantsBlood-Brain BarrierDose-Response Relationship, DrugHumansMolecular Docking SimulationMolecular StructurePeptide FragmentsStructure-Activity RelationshipAcetylcholinesteraseAminoquinolinesamiridineAmyloid beta-Peptidesamyloid beta-protein (1-42)AntioxidantsButyrylcholinesteraseCholinesterase InhibitorsPeptide FragmentsAlzheimer's diseaseamiridinemultifunctional activitysalicylic derivatives

Identifiers

PMID39686878
PMCPMC11650361

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.