ArticleJournal of cachexia, sarcopenia and muscle2025
Muscle Mass Index Decline as a Predictor of Lung Function Reduction in the General Population.
Article in Journal of cachexia, sarcopenia and muscle, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Association Between COPD, Acute Exacerbations of COPD, and Survival in COPD, with Fat-Free Body Mass Index: A Systematic Review and Meta-Analysis.International journal of chronic obstructive pulmonary disease · 2025Pooled it
- Associations between body mass index and peak expiratory flow rate and the mediating role of hand grip strength: evidence from CHARLS.Clinics (Sao Paulo, Brazil) · 2026Article
- Prognostic value of long-term trajectory linearity in rapid lung function decline.ERJ open research · 2026Article
- Effect of Socioeconomic Status on Lung Function in the Korean General Population.Journal of Korean medical science · 2026Article
- The lung-muscle axis in COPD: a conceptual framework integrating evidence, mechanisms, and therapeutic perspectives.Frontiers in immunology · 2026Review
- Associations of LDL and HDL cholesterol with lung function decline and risk of airflow obstruction in a community-based cohort.Scientific reports · 2025Observational
- Non-pharmacologic Prevention of Acute Exacerbation Chronic Obstructive Pulmonary Disease.Tuberculosis and respiratory diseases · 2025Article
- Biomarkers of aging: from molecules and surrogates to physiology and function.Physiological reviews · 2025Review
- Association between bone mineral density T-score and respiratory sarcopenia in older adults.Frontiers in medicine · 2025Article
- Association between estimated glucose disposal rate and preserved ratio impaired spirometry in adults.Frontiers in endocrinology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
backgroundThis study explores the link between muscle mass decline and lung function deterioration, which can worsen respiratory health by reducing exercise capacity and quality of life. The relationship between muscle mass index (MMI) changes and lung function in the general population remains unclear, especially as muscle mass fluctuates with aging. We aimed to clarify this dynamic relationship by examining how changes in muscle mass impact pulmonary function and the development of respiratory symptoms.
methodsWe utilized the Ansan and Ansung Cohort Study of the Korean Genome and Epidemiology Study (KoGES) database, a large-scale prospective cohort, enrolling participants aged 40 to 69 years with lung function and body composition measurements. Over 12 years, data were collected biannually. The study assessed associations between changes in MMI and lung function trends, with cT1-T3 calculated using the linear regression coefficient and stratified by tertile. Survival analysis was then performed to examine differences in time to first airflow obstruction (AFO) and exacerbation among the tertiles.
resultsA total of 2956 participants were enrolled in this study. At baseline, participants with higher MMI tended to be younger, had fewer co-morbidities and exhibited better lung function. Those with a steeper MMI decline rate exhibited a more rapid forced expiratory volume in 1 s (FEV
conclusionsA faster decline in MMI was associated with more rapid decline of both FEV
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.