Evidence map›Paper›PMID 39686852›Full record

ArticleBiomarkers in medicine2025

Hematological markers as prognostic indicators in multiple sclerosis progression.

Maryam Poursadeghfard, Samin Shiati, Mohammad Saied Salehi, Aryan Khani, Soheil Vafaeian, Mahnaz Bayat, Etrat Hooshmandi

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Article in Biomarkers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Maryam PoursadeghfardClinical Neurology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Samin ShiatiStudent Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.
Mohammad Saied SalehiClinical Neurology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Aryan KhaniClinical Neurology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Soheil VafaeianClinical Neurology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Mahnaz BayatClinical Neurology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Etrat HooshmandiClinical Neurology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.ORCID 0000-0002-6097-9316

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsTo evaluate routine blood count parameters as diagnostic and prognostic markers in Multiple Sclerosis (MS) progression. PATIENTS/

methods182 patients with Relapsing-Remitting MS (RRMS) and 60 with Secondary Progressive MS (SPMS) were analyzed for blood parameters.

resultsIn RRMS, the Expanded Disability Status Scale (EDSS) score correlated positively with Red Cell Distribution Width (RDW). In SPMS, the EDSS score correlated positively with White Blood Cell count (WBC) and Mean Platelet Volume (MPV). RDW predicted higher EDSS scores in RRMS, while MPV was a predictor in SPMS. Elevated MPV levels characterized the increased risk of transitioning from RRMS to SPMS.

conclusionsElevated MPV may serve as a significant indicator of disease progression from RRMS to SPMS, emphasizing its potential clinical relevance.

Indexed as

BiomarkersDisease ProgressionMean Platelet VolumeAdultErythrocyte IndicesFemaleHumansLeukocyte CountMaleMiddle AgedMultiple SclerosisMultiple Sclerosis, Chronic ProgressiveMultiple Sclerosis, Relapsing-RemittingPrognosisBiomarkersEDSSmean platelet volumeMultiple sclerosisprognosisred cell distribution width

Identifiers

PMID39686852
PMCPMC11731226

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