ArticleAddiction biology2024
Reduced brain network segregation in alcohol use disorder: Associations with neurocognition.
Article in Addiction biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed.
- Long-Acting Naltrexone Restores Network Connectivity in Subjects With Comorbid Cannabis and Opioid Use Disorder.Addiction biology · 2026Article
- Reduced Whole-Brain Network Segregation and Dorsal Anterior-Cingulate Cortex Neurochemical Alterations in Chronic Smokers.Brain and behavior · 2026Article
- Cognitive Functioning in Abstinent Patients with Alcohol Use Disorder: Exploring Evidence for Premature Aging.Brain sciences · 2026Article
- Long-acting naltrexone restores network connectivity in subjects with co-morbid cannabis and opioid use disorder.bioRxiv : the preprint server for biology · 2025Article
- Brain network segregation is associated with drug use severity in individuals with opioid use disorder.Drug and alcohol dependence · 2025Article
- Accelerated brain aging in alcohol users: Insights from machine learning.Alcohol, clinical & experimental research · 2025Article
- Altered integrated and segregated states in cocaine use disorder.Frontiers in neuroscience · 2025Article
- Reduced brain network segregation in alcohol use disorder: Associations with neurocognition.Addiction biology · 2024Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
The human brain consists of functionally segregated networks, characterized by strong connections among regions belonging to the same network and weak connections between those of different networks. Alcohol use disorder (AUD) is associated with premature brain aging and neurocognitive impairments. Given the link between decreased brain network segregation and age-related cognitive decline, we hypothesized lower brain segregation in patients with AUD than healthy controls (HCs). Thirty AUD patients (9 females, 21 males) and 61 HCs (35 females, 26 males) underwent resting-state functional MRI (rs-fMRI), whose data were processed to assess segregation within the brain sensorimotor and association networks. We found that, compared to HCs, AUD patients had significantly lower segregation in both brain networks as well as poorer performance on a spatial working memory task. In the HC group, brain network segregation correlated negatively with age and positively with spatial working memory. Our findings suggest reduced brain network segregation in individuals with AUD that may contribute to cognitive impairment and is consistent with premature brain aging in this population.
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Registered trials
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