ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025
Thermosensitive Hydrogel Integrated with Bimetallic Nano-Enzymes for Modulating the Microenvironment in Diabetic Wound Beds.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed.
- Electron-rearranged CuMg@ZIF nanoplatform for pH-Responsive sequential therapy: From infection eradication to neuroangiogenesis in diabetic wounds.Bioactive materials · 2027Article
- Magneto-Sono-Enhanced Nanozyme Catalysis Drives ROS-Mediated Pathogen Killing and Mitophagy-Linked Inflammation Control in Bacterial Pneumonia.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Bioelectric Reawakening by a Self-Powered Thermoelectric Hydrogel Accelerates Diabetic Ulcer Repair.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Thermosensitive citrate-based mussel-inspired attack-defense integrated bioadhesives facilitate complicated wound healing.Bioactive materials · 2026Article
- Biomimetic materials for medical applications.Chinese medical journal · 2026Review
- Highly bio-adapted hydrogels for tendon-bone interface regeneration: Natural healing inspiration, design strategies, and biomedical potential.Bioactive materials · 2026Review
- Metal-Organic Framework Nanozymes: From Rational Design and Synthesis to Biomedical Applications.Nano-micro letters · 2026Review
- Novel AI-Driven Precision Strategies in Diabetic Wound Healing: Immunomodulation and Advances in Smart Composite Nanocarriers.Pharmaceutics · 2026Review
- Emerging Nanomaterials Can Even Treat Chronic Wounds: A Review of Evidence on Magnesium-Based Systems.International journal of nanomedicine · 2026Review
- Biomaterial-mediated remodelling of the inflammatory microenvironment: a pH/ROS-responsive EGCG-metformin hydrogel for infected diabetic wound regeneration.Frontiers in cell and developmental biology · 2026Article
- Emerging Biomedical Engineering Therapies for Infected Diabetic Foot Ulcers: Toward Antibacterial Functionalization and Pathology-Responsive Regulation.Small science · 2026Review
- Recent Advances in Nanozymes Toward Diabetic Foot Ulcers.International journal of nanomedicine · 2026Review
- Stimuli-Responsive Chitosan Hydrogels for Diabetic Wound Management: Comprehensive Review of Emerging Strategies.Biomimetics (Basel, Switzerland) · 2025Review
- Bimetallic and multimetallic nanozymes: synergistic catalysis for advanced biomedical and health applications.RSC advances · 2025Review
- Thermosensitive polygalacturonic acid glycoprotein hydrogel encapsulating bionic shikonin nanoparticles for the treatment of psoriasis.Materials today. Bio · 2025Article
- Natural Bioactive Compound-Integrated Nanomaterials for Diabetic Wound Healing: Synergistic Effects, Multifunctional Designs, and Challenges.Molecules (Basel, Switzerland) · 2025Review
- Natural Products for Improving Soft Tissue Healing: Mechanisms, Innovations, and Clinical Potential.Pharmaceutics · 2025Review
- Review
- The Journey of Copper-Impregnated Dressings in Wound Healing: From a Medical Hypothesis to Clinical Practice.Biomedicines · 2025Review
- Thermosensitive Hydrogel Integrated with Bimetallic Nano-Enzymes for Modulating the Microenvironment in Diabetic Wound Beds.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
Effective regulation and reconstruction of the microenvironment are critical for the regeneration of chronic wounds. Diabetic wounds, in particular, pose a significant clinical challenge due to increased oxidative stress and dysfunctional healing processes. In this study, a novel therapeutic strategy is developed using 3D copper-magnesium bimetallic antioxidant nano-enzymes (Cu/Mg-MOF) to mitigate reactive oxygen species (ROS) and restore redox balance through electron transfer. To optimize delivery, a thermo-sensitive hydrogel composed of chitosan (CS) and ε-polylysine (PL) is designed, serving as an efficient carrier for the nano-enzymes. This Cu/Mg-MOF@CS/PL hydrogel exhibits excellent physical properties, including injectability, softness, and biocompatibility, making it ideal for application in diabetic wounds. In a diabetic wound model, treatment with Cu/Mg-MOF@CS/PL hydrogel significantly accelerated wound healing, with a closure rate of 90.6% by day 14, compared to just 55.4% in the untreated group. The hydrogel effectively promoted key aspects of wound healing, such as collagen deposition, re-epithelialization, angiogenesis, and immunomodulation. These findings underscore the potential of the Cu/Mg-MOF@CS/PL hydrogel as a promising therapeutic system for enhancing the healing of diabetic wounds.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.