Evidence map›Paper›PMID 39686680›Full record

SynthesisAge and ageing2024

The association between delirium and falls in older adults in the community: a systematic review and meta-analysis.

Charlotte Eost-Telling, Lucy McNally, Yang Yang, Chunhu Shi, Gill Norman, Saima Ahmed, Brenda Poku, Annemarie Money, Helen Hawley-Hague, Chris J Todd and 2 more

Abstract readSystematic ReviewMeta-Analysis
In one paragraph

Synthesis in Age and ageing, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Charlotte Eost-TellingNational Institute for Health and Care Research (NIHR), Applied Research Collaboration Greater Manchester, School of Health Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.ORCID 0000-0002-9568-3195
Lucy McNallySchool of Medicine, Dentistry and Health, University of Glasgow, Glasgow, UK.
Yang YangDivision of Nursing Midwifery and Social Work, School of Health Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.ORCID 0000-0002-2283-5266
Chunhu ShiNational Institute for Health and Care Research (NIHR), Applied Research Collaboration Greater Manchester, School of Health Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.
Gill NormanEvidence Synthesis Group, Newcastle University Population Health Sciences Institute, Newcastle upon Tyne, UK.ORCID 0000-0002-3972-5733
Saima AhmedNational Institute for Health and Care Research (NIHR), Applied Research Collaboration Greater Manchester, School of Health Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.ORCID 0000-0002-6206-3184
Brenda PokuSchool of Sociology and Social Policy, University of Nottingham, Nottingham, UK.ORCID 0000-0002-2265-7041
Annemarie MoneyNational Institute for Health and Care Research (NIHR), Applied Research Collaboration Greater Manchester, School of Health Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.ORCID 0000-0003-1714-2470
Helen Hawley-HagueDivision of Nursing Midwifery and Social Work, School of Health Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.ORCID 0000-0002-2451-4482
Chris J ToddNational Institute for Health and Care Research (NIHR), Applied Research Collaboration Greater Manchester, School of Health Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.ORCID 0000-0001-6645-4505
Susan Deborah ShenkinAgeing and Health, The University of Edinburgh Usher Institute, Edinburgh, UK.ORCID 0000-0001-7375-4776
Emma R L C VardyNational Institute for Health and Care Research (NIHR), Applied Research Collaboration Greater Manchester, School of Health Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.ORCID 0000-0002-3457-9757

Funding

National Institute for Health and Care Research NIHR200174
6 · The paper itself

Abstract

objectiveSystematically review and critically appraise the evidence for the association between delirium and falls in community-dwelling adults aged ≥60 years.

methodsWe searched EMBASE, MEDLINE, PsycINFO, Cochrane Database of Systematic Reviews, CINAHL and Evidence-Based Medicine Reviews databases in April 2023. Standard methods were used to screen, extract data, assess risk of bias (using Newcastle-Ottawa scale), provide a narrative synthesis and, where appropriate, conduct meta-analysis.

resultsWe included 8 studies, with at least 3505 unique participants. Five found limited evidence for an association between delirium and subsequent falls: one adjusted study showed an increase in falls (risk ratio 6.66; 95% confidence interval (CI) 2.16-20.53), but the evidence was low certainty. Four non-adjusted studies found no clear effect. Three studies (one with two subgroups treated separately) found some evidence for an association between falls and subsequent delirium: meta-analysis of three adjusted studies showed an increase in delirium (pooled odds ratio 2.01; 95% CI 1.52-2.66); one subgroup of non-adjusted data found no clear effect. Number of falls and fallers were reported in the studies. Four studies and one subgroup were at high risk of bias and one study had some concerns.

conclusionsWe found limited evidence for the association between delirium and falls. More methodologically rigorous research is needed to understand the complex relationship and establish how and why this operates bidirectionally. Studies must consider confounding factors such as dementia, frailty and comorbidity in their design, to identify potential modifying factors involved. Clinicians should be aware of the potential relationship between these common presentations.

Indexed as

Accidental FallsDeliriumIndependent LivingAgedAged, 80 and overFemaleHumansMaleMiddle AgedRisk AssessmentRisk Factorscommunitydeliriumfallsolder adultsolder peoplesystematic review

Identifiers

PMID39686680
PMCPMC11649760

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.