Evidence map›Paper›PMID 39686647›Full record

ArticleEuropean journal of neurology2025

Brain microstructural damage through serial diffusion tensor imaging and outcomes in Susac syndrome: A prospective cohort study.

Augustin Gaudemer, Marie-Cécile Henry-Feugeas, Marion Peyre, Alexandra Kachaner, Isabelle Klein, Antoine Khalil, Thomas Papo, Karim Sacré

Registry-linked trialAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01481662 (Epidemiological, Clinical and Etiological Features of SUSAC's Syndrome), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01481662 unknown statusnot on this map

Epidemiological, Clinical and Etiological Features of SUSAC's Syndrome (RETINOCOCHLEOCEREBRAL Vasculopathy)

TypeobservationalSponsorAssistance Publique - Hôpitaux de ParisRan2011 to 2021Enrolled100ConditionsSUSAC's Syndrome, Encephalopathy, Hearing Loss, Retinal Artery Branch OcclusionsArmsDiffusion tensor magnetic resonance imaging of the brain
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Augustin GaudemerDepartment of Radiology, Hospital Bichat-Claude Bernard, Assistance Publique Hôpitaux de Paris, Université Paris Cité, Paris, France.
Marie-Cécile Henry-FeugeasDepartment of Radiology, Hospital Bichat-Claude Bernard, Assistance Publique Hôpitaux de Paris, Université Paris Cité, Paris, France.
Marion PeyreDepartment of Internal Medicine, Hospital Bichat-Claude Bernard, Assistance Publique Hôpitaux de Paris, Université Paris Cité, Paris, France.
Alexandra KachanerDepartment of Internal Medicine, Hospital Bichat-Claude Bernard, Assistance Publique Hôpitaux de Paris, Université Paris Cité, Paris, France.
Isabelle KleinDepartment of Radiology, Clinique Alleray-Labrouste, Paris, France.
Antoine KhalilDepartment of Radiology, Hospital Bichat-Claude Bernard, Assistance Publique Hôpitaux de Paris, Université Paris Cité, Paris, France.
Thomas PapoDepartment of Internal Medicine, Hospital Bichat-Claude Bernard, Assistance Publique Hôpitaux de Paris, Université Paris Cité, Paris, France.
Karim SacréDepartment of Internal Medicine, Hospital Bichat-Claude Bernard, Assistance Publique Hôpitaux de Paris, Université Paris Cité, Paris, France.ORCID 0000-0002-6544-234X

Funding

Assistance Publique Hôpitaux de ParisMinistère de la Santé CRC 2019-19059Ministère de la Santé PHRC 2005-090039Université de Paris
6 · The paper itself

Abstract

backgroundSusac syndrome (SuS) is a rare immune-mediated microangiopathy with potential disabling evolution. We aimed to analyze brain microstructural damage through diffusion tensor imaging (DTI) in SuS and determine its association with poor outcomes.

methodCarESS study is a prospective multicenter national cohort study of patients with SuS. Patients included at the principal investigator's center with at least two available brain magnetic resonance imaging (MRI) with DTI were analyzed. Mean diffusivity (MD) and fractional anisotropy (FA) were measured in fibers crossing three regions of interest (ROIs): the corpus callosum as a whole, the genu of the corpus callosum, and the splenium of the corpus callosum. The primary outcome was work resumption.

resultsTwenty-two patients (36 (25;42) years, 16 (73%) females) were studied. The triad (i.e., brain, eye, and ear involvement) was complete in 21 (95%) patients. All but one patients received steroids alone or in combination with immunosuppressive drugs (n = 11) and/or IVIg (n = 7). Over a median follow-up of 6 (5;8) years, 15 (68%) patients went back to work. FA and MD were longitudinally measured in 123 DTI MRI accounting for a median of 5.6 [4.2; 7] MRI per patient. Microstructural damages in the corpus callosum as a whole, the genu of the corpus callosum, and the splenium of the corpus callosum increased during follow-up and were significantly associated with the inability to return to work.

conclusionBrain DTI identified microstructural damage in fibers crossing the corpus callosum that are associated with long-term disability in SuS.

trial registrationClinicalTrials.gov portal identifier: NCT01481662 (https://clinicaltrials.gov/ct2/show/NCT01481662?term=caress&draw=2&rank=5).

Indexed as

Diffusion Tensor ImagingSusac SyndromeAdultBrainCohort StudiesCorpus CallosumFemaleHumansMaleProspective Studiesbrain microstructural damagediffusion tensor imagingoutcomeSusac syndrome

Identifiers

PMID39686647
PMCPMC11649952

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Registered trials

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