Evidence map›Paper›PMID 39686588›Full record

ArticleDevelopmental neurobiology2025

Novel Transgenic Zebrafish Lines to Study the CHRNA3-B4-A5 Gene Cluster.

Yuanqi Hua, Judith Habicher, Matthias Carl, Remy Manuel, Henrik Boije

Abstract read
In one paragraph

Article in Developmental neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Disruption ofiScience · 2026
    Article
  4. The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yuanqi HuaDepartment of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
Judith HabicherDepartment of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
Matthias CarlDepartment of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, Trento, Italy.
Remy ManuelDepartment of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
Henrik BoijeDepartment of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.ORCID 0000-0002-4877-9725

Funding

Ake Wibergs FoundationCarl Tryggers FoundationJeanssons foundationKjell and Marta BeijersMagnus Bergvalls FoundationOlle Engkvists StiftelseRoyal Swedish Academy of SciencesStiftelsen för Strategisk ForskningSvenska Forskningsrådet FormasSwedish Brain Foundationthe Ragnar Söderberg FoundationVetenskapsrådet
6 · The paper itself

Abstract

Acetylcholine (ACh), a vital neurotransmitter for both the peripheral (PNS) and central nervous systems (CNS), signals through nicotinic ACh receptors (nAChRs) and muscarinic ACh receptors (mAChR). Here, we explore the expression patterns of three nAChR subunits, chrna3, chrnb4, and chrna5, which are located in an evolutionary conserved cluster. This close genomic positioning, in a range of vertebrates, may indicate co-functionality and/or co-expression. Through novel transgenic zebrafish lines, we observe widespread expression within both the PNS and CNS. In the PNS, we observed expression of chrna3

Indexed as

Animals, Genetically ModifiedMultigene FamilyReceptors, NicotinicZebrafishAnimalsCentral Nervous SystemZebrafish ProteinsReceptors, NicotinicZebrafish Proteinsacetylcholine (ACh)Danio rerionervous systemnicotinic acetylcholine receptors (nAChRs)spinal cord

Identifiers

PMID39686588
PMCPMC11650009

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.