Evidence map›Paper›PMID 39685057›Full record

ReviewHealthcare (Basel, Switzerland)2024

The Effect of Endometriosis on In Vitro Fertilization Outcomes: A Systematic Review and Meta-Analysis.

Ilenia Mappa, Zoe Pauline Page, Daniele Di Mascio, Chiara Patelli, Francesco D'Antonio, Antonella Giancotti, Francesco Gebbia, Giulia Mariani, Mauro Cozzolino, Ludovico Muzii and 1 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Healthcare (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Observational
  3. Review
  4. Review
  5. Review
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ilenia MappaDepartment of Obstetrics and Gynecology, Fondazione Policlinico di Tor Vergata, University of Rome Tor Vergata, 00133 Roma, Italy.
Zoe Pauline PageDepartment of Obstetrics and Gynecology, Fondazione Policlinico di Tor Vergata, University of Rome Tor Vergata, 00133 Roma, Italy.
Daniele Di MascioDepartment of Maternal and Child Health and Urological Sciences, Sapienza University of Rome, 00185 Roma, Italy.ORCID 0000-0002-6560-3393
Chiara PatelliDepartment of Obstetrics and Gynecology, University of Verona, 37129 Verona, Italy.
Francesco D'AntonioDepartment of Obstetrics and Gynecology, University of Chieti, 66013 Chieti, Italy.
Antonella GiancottiDepartment of Maternal and Child Health and Urological Sciences, Sapienza University of Rome, 00185 Roma, Italy.
Francesco GebbiaIVIRMA Global Research Alliance, IVI Roma-Rome, 00197 Roma, Italy.
Giulia MarianiIVIRMA Global Research Alliance, IVI Roma-Rome, 00197 Roma, Italy.
Mauro CozzolinoIVIRMA Global Research Alliance, IVI Roma-Rome, 00197 Roma, Italy.ORCID 0000-0002-5929-2357
Ludovico MuziiDepartment of Maternal and Child Health and Urological Sciences, Sapienza University of Rome, 00185 Roma, Italy.ORCID 0000-0001-7195-9583
Giuseppe RizzoDepartment of Maternal and Child Health and Urological Sciences, Sapienza University of Rome, 00185 Roma, Italy.ORCID 0000-0002-5525-4353

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe purpose of this study was to evaluate the impact of endometriosis on various outcomes of in vitro fertilization (IVF), including live birth rates, clinical pregnancy rates, fertilization rates, and implantation rates, through a systematic review and meta-analysis.

methodsSystematic searches were carried out using PubMed, MEDLINE, Cochrane Central Register of Controlled Trials, Scopus, EMBASE, and Web of Science from January 2010 to November 2023. Studies comparing IVF outcomes in women with and without endometriosis were included. The primary outcome was live birth rate; secondary outcomes included clinical pregnancy, fertilization, and implantation rates. Data were extracted and analyzed using odds ratio (OR) and 95% confidence interval (CI) with fixed or random-effects models, depending on heterogeneity.

resultsFrom 1340 studies initially identified, 40 studies met the inclusion criteria, encompassing 8970 women with endometriosis and 42,946 control participants. There were no significant differences between the endometriosis and control groups in terms of live birth rate (OR 1.03, 95% CI 0.75-1.41,

conclusionsEndometriosis significantly negatively affects implantation rates in women undergoing IVF, despite the absence of significant differences in live birth, clinical pregnancy, and fertilization rates. Further research is needed to evaluate the impact of different stages of endometriosis on IVF outcomes and to develop optimized management protocols for these patients.

Indexed as

clinical pregnancy rateendometriosisfertilization rateimplantation rateIVFlive birth ratemeta-analysis

Identifiers

PMID39685057
PMCPMC11641477

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.