Evidence map›Paper›PMID 39684938›Full record

ArticleInternational journal of molecular sciences2024

Effect of Organic Anion Transporting Polypeptide 1B1 on Plasma Concentration Dynamics of Clozapine in Patients with Treatment-Resistant Schizophrenia.

Toshihiro Sato, Takeshi Kawabata, Masaki Kumondai, Nagomi Hayashi, Hiroshi Komatsu, Yuki Kikuchi, Go Onoguchi, Yu Sato, Kei Nanatani, Masahiro Hiratsuka and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Toshihiro SatoDepartment of Pharmaceutical Sciences, Tohoku University Hospital, Sendai 980-8574, Japan.ORCID 0000-0002-8807-2417
Takeshi KawabataGraduate School of Information Sciences, Tohoku University, Sendai 980-8578, Japan.ORCID 0000-0002-0032-9688
Masaki KumondaiDepartment of Pharmaceutical Sciences, Tohoku University Hospital, Sendai 980-8574, Japan.ORCID 0000-0002-2333-2847
Nagomi HayashiFaculty of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan.
Hiroshi KomatsuDepartment of Psychiatry, Tohoku University Hospital, Sendai 980-8574, Japan.ORCID 0000-0002-7602-0281
Yuki KikuchiDepartment of Psychiatry, Graduate School of Medicine, Tohoku University, Sendai 980-8575, Japan.ORCID 0000-0002-1184-8918
Go OnoguchiDepartment of Psychiatry, Tohoku University Hospital, Sendai 980-8574, Japan.
Yu SatoDepartment of Pharmaceutical Sciences, Tohoku University Hospital, Sendai 980-8574, Japan.ORCID 0000-0002-8979-2408
Kei NanataniAdvanced Research Center for Innovations in Next-Generation Medicine, Tohoku University, Sendai 980-8573, Japan.ORCID 0000-0002-8614-6208
Masahiro HiratsukaDepartment of Pharmaceutical Sciences, Tohoku University Hospital, Sendai 980-8574, Japan.ORCID 0000-0002-3767-7686
Masamitsu MaekawaDepartment of Pharmaceutical Sciences, Tohoku University Hospital, Sendai 980-8574, Japan.ORCID 0000-0001-6723-0298
Hiroaki YamaguchiDepartment of Pharmacy, Yamagata University Hospital, Yamagata 990-9585, Japan.ORCID 0000-0003-3021-6120
Takaaki AbeDivision of Nephrology, Endocrinology, and Vascular Medicine, Graduate School of Medicine, Tohoku University, Sendai 980-8574, Japan.
Hiroaki TomitaDepartment of Psychiatry, Tohoku University Hospital, Sendai 980-8574, Japan.ORCID 0000-0003-2628-880X
Nariyasu ManoDepartment of Pharmaceutical Sciences, Tohoku University Hospital, Sendai 980-8574, Japan.

Funding

Research grant from Japan Research Foundation for Clinical Pharmacology NAThe Clinical Research Promotion Program for Young Investigators of Tohoku University Hospital NA
6 · The paper itself

Abstract

The involvement of drug-metabolizing enzymes and transporters in plasma clozapine (CLZ) dynamics has not been well examined in Japanese patients with treatment-resistant schizophrenia (TRS). Therefore, this clinical study investigated the relationship between single nucleotide polymorphisms (SNPs) of various pharmacokinetic factors (drug-metabolizing enzymes and transporters) and dynamic changes in CLZ. Additionally, we aimed to determine whether CLZ acts as a substrate for pharmacokinetic factors using in vitro assays and molecular docking calculations. We found that 6 out of 10 patients with TRS and with multiple organic anion transporting polypeptide (OATP) variants (OATP1B1:

Indexed as

ClozapineLiver-Specific Organic Anion Transporter 1Molecular Docking SimulationPolymorphism, Single NucleotideAdultAntipsychotic AgentsFemaleHEK293 CellsHumansMaleMiddle AgedOrganic Anion TransportersSchizophreniaSchizophrenia, Treatment-ResistantAntipsychotic AgentsClozapineLiver-Specific Organic Anion Transporter 1Organic Anion TransportersSLCO1B1 protein, humanclozapineJapanesenorclozapineOATP1B1SNPtreatment-resistant schizophrenia

Identifiers

PMID39684938
PMCPMC11642635

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.