Evidence map›Paper›PMID 39684926›Full record

ArticleInternational journal of molecular sciences2024

Integrated Transcriptomic and Proteomic Analyses of Antler Growth and Ossification Mechanisms.

Ruijia Liu, Pan Zhang, Jiade Bai, Zhenyu Zhong, Yunfang Shan, Zhibin Cheng, Qingxun Zhang, Qingyun Guo, Hao Zhang, Bo Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ruijia LiuState Key Laboratory of Animal Biotech Breeding, Beijing Key Laboratory for Animal Genetic Improvement, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.ORCID 0009-0006-3841-3806
Pan ZhangBeijing Milu Ecological Research Center, Beijing Academy of Science and Technology, Beijing 100076, China.
Jiade BaiBeijing Milu Ecological Research Center, Beijing Academy of Science and Technology, Beijing 100076, China.
Zhenyu ZhongBeijing Milu Ecological Research Center, Beijing Academy of Science and Technology, Beijing 100076, China.
Yunfang ShanBeijing Milu Ecological Research Center, Beijing Academy of Science and Technology, Beijing 100076, China.
Zhibin ChengBeijing Milu Ecological Research Center, Beijing Academy of Science and Technology, Beijing 100076, China.
Qingxun ZhangBeijing Milu Ecological Research Center, Beijing Academy of Science and Technology, Beijing 100076, China.ORCID 0000-0002-6674-9204
Qingyun GuoBeijing Milu Ecological Research Center, Beijing Academy of Science and Technology, Beijing 100076, China.ORCID 0000-0002-8053-1922
Hao ZhangState Key Laboratory of Animal Biotech Breeding, Beijing Key Laboratory for Animal Genetic Improvement, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.ORCID 0000-0003-4093-5647
Bo ZhangState Key Laboratory of Animal Biotech Breeding, Beijing Key Laboratory for Animal Genetic Improvement, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.ORCID 0000-0002-7331-1550

Funding

Beijing Academy of Science and Technology Financial Support Projects 23CB063 and 24CE-BGS-09
6 · The paper itself

Abstract

Antlers are the sole mammalian organs capable of continuous regeneration. This distinctive feature has evolved into various biomedical models. Research on mechanisms of antler growth, development, and ossification provides valuable insights for limb regeneration, cartilage-related diseases, and cancer mechanisms. Here, ribonucleic acid sequencing (RNA-seq) and four-dimensional data-independent acquisition (4D DIA) technologies were employed to examine gene and protein expression differences among four tissue layers of the Chinese milu deer antler: reserve mesenchyme (RM), precartilage (PC), transition zone (TZ), cartilage (CA). Overall, 4611 differentially expressed genes (DEGs) and 2388 differentially expressed proteins (DEPs) were identified in the transcriptome and proteome, respectively. Among the 828 DEGs common to both omics approaches, genes from the collagen, integrin, and solute carrier families, and signaling molecules were emphasized for their roles in the regulation of antler growth, development, and ossification. Bioinformatics analysis revealed that in addition to being regulated by vascular and nerve regeneration pathways, antler growth and development are significantly influenced by numerous cancer-related signaling pathways. This indicates that antler growth mechanisms may be similar to those of cancer cell proliferation and development. This study lays a foundation for future research on the mechanisms underlying the rapid growth and ossification of antlers.

Indexed as

AntlersDeerOsteogenesisProteomicsTranscriptomeAnimalsComputational BiologyGene Expression ProfilingGene Expression Regulation, DevelopmentalProteomeProteome4D DIAantler regenerationChinese milu deerossificationvelvet antler

Identifiers

PMID39684926
PMCPMC11642661

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.