Evidence map›Paper›PMID 39684886›Full record

ArticleInternational journal of molecular sciences2024

Development of Novel Imipridones with Alkyne- and Triazole-Linked Warheads on the Tricyclic Skeleton, Showing Superior Ability to Eradicate PANC-1 and Fadu Cells Compared to ONC201.

Tamás Czuczi, József Murányi, István Móra, Bianka Gurbi, Attila Varga, Dávid Papp, Gitta Schlosser, Miklós Csala, Antal Csámpai

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Tamás CzucziDepartment of Organic Chemistry, Eötvös Loránd University (ELTE), Pázmány P. Sétány 1/A, H-1117 Budapest, Hungary.
József MurányiDepartment of Organic Chemistry, Eötvös Loránd University (ELTE), Pázmány P. Sétány 1/A, H-1117 Budapest, Hungary.ORCID 0000-0001-5672-6482
István MóraDepartment of Molecular Biology, Semmelweis University, Tűzoltó u. 37-47, H-1094 Budapest, Hungary.ORCID 0000-0003-3127-7881
Bianka GurbiDepartment of Molecular Biology, Semmelweis University, Tűzoltó u. 37-47, H-1094 Budapest, Hungary.ORCID 0000-0002-5635-6255
Attila VargaDepartment of Molecular Biology, Semmelweis University, Tűzoltó u. 37-47, H-1094 Budapest, Hungary.
Dávid PappHevesy György PhD School of Chemistry, Pázmány P. Sétány 1/A, H-1117 Budapest, Hungary.ORCID 0000-0002-2006-7777
Gitta SchlosserMTA-ELTE Lendület (Momentum) Ion Mobility Mass Spectrometry Research Group, Institute of Chemistry, ELTE Eötvös Loránd University, Pázmány Péter Sétány 1/A, H-1117 Budapest, Hungary.ORCID 0000-0002-7637-7133
Miklós CsalaDepartment of Molecular Biology, Semmelweis University, Tűzoltó u. 37-47, H-1094 Budapest, Hungary.ORCID 0000-0002-3829-4361
Antal CsámpaiDepartment of Organic Chemistry, Eötvös Loránd University (ELTE), Pázmány P. Sétány 1/A, H-1117 Budapest, Hungary.ORCID 0000-0003-2107-7309

Funding

ELTE Thematic Excellence Programme Synth+ 1117Hungarian Ministry for Innovation and Technology and the Lendület (Momentum) Programme of the Hungarian Academy of Sciences TKP2021-EGA-24Hungarian Scientific Research Fund K_129037
6 · The paper itself

Abstract

Our ongoing research focuses on the development of new imipridone derivatives. We aim to design compounds that can completely and selectively eradicate cancer cells after relatively short treatment. We have synthetized systematically designed novel hybrids and evaluated their antiproliferative activity against PANC-1 and Fadu cell lines. We have also conducted preliminary studies on the mechanism, including colony formation as well as dose-response tests in HEK293T wild-type (WT) and HEK293T CLPP

Indexed as

AlkynesAntineoplastic AgentsTriazolesCell Line, TumorCell ProliferationHEK293 CellsHumansStructure-Activity RelationshipAlkynesAntineoplastic AgentsTriazoles1,2,3-triazolecell viabilityClpP-independent mechanismcolony formationcomplete eradication of cancer cellsCuAAc reactiondose–response measurementsimipridonePANC-1 and Fadu cellspropargylamineSonogashira coupling

Identifiers

PMID39684886
PMCPMC11642016

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.