Evidence map›Paper›PMID 39684842›Full record

ArticleInternational journal of molecular sciences2024

Evaluation of Spliceosome Protein SmD2 as a Potential Target for Cancer Therapy.

Jing Li, Peiyu Li, Tereza Brachtlova, Ida H van der Meulen-Muileman, Henk Dekker, Vishal S Kumar, Marieke Fransen, Idris Bahce, Emanuela Felley-Bosco, Victor W van Beusechem

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Integrated analysis uncoversInternational journal of medical sciences · 2026
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jing LiAmsterdam UMC location Vrije Universiteit Amsterdam, Medical Oncology, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands.
Peiyu LiAmsterdam UMC location Vrije Universiteit Amsterdam, Medical Oncology, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands.
Tereza BrachtlovaAmsterdam UMC location Vrije Universiteit Amsterdam, Medical Oncology, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands.
Ida H van der Meulen-MuilemanAmsterdam UMC location Vrije Universiteit Amsterdam, Medical Oncology, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands.
Henk DekkerAmsterdam UMC location Vrije Universiteit Amsterdam, Medical Oncology, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands.
Vishal S KumarAmsterdam UMC location Vrije Universiteit Amsterdam, Medical Oncology, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands.
Marieke FransenCancer Center Amsterdam, Cancer Biology and Immunology, 1081 HV Amsterdam, The Netherlands.ORCID 0000-0003-3036-8618
Idris BahceAmsterdam Institute for Infection and Immunity, Cancer Immunology, 1081 HV Amsterdam, The Netherlands.
Emanuela Felley-BoscoDepartment of Biomedical Sciences, University of Lausanne, Rue du Bugnon 7, CH-1005 Lausanne, Switzerland.ORCID 0000-0002-3408-0294
Victor W van BeusechemAmsterdam UMC location Vrije Universiteit Amsterdam, Medical Oncology, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands.

Funding

China Scholarship Council 201807040045 and 202208140002Walter Bruckerhoff Stiftung no
6 · The paper itself

Abstract

The core spliceosome Sm proteins are gaining attention as potential targets for cancer treatment. Here, we evaluate this, with focus on SmD2. A pan-cancer analysis including 26 solid tumor types revealed that the SmD2-encoding

Indexed as

NeoplasmsSpliceosomesAntineoplastic AgentsCell Line, TumorGene Expression Regulation, NeoplasticHumansMolecular Targeted TherapyRNA SplicingAntineoplastic Agentsdrug sensitivitymitosispan-cancer analysisSm proteinsSNRPD2 dependency

Identifiers

PMID39684842
PMCPMC11642717

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.