Evidence map›Paper›PMID 39684824›Full record

ArticleInternational journal of molecular sciences2024

Spatially Resolved Molecular Characterization of Noninvasive Follicular Thyroid Neoplasms with Papillary-like Nuclear Features (NIFTPs) Identifies a Distinct Proteomic Signature Associated with RAS-Mutant Lesions.

Vanna Denti, Angela Greco, Antonio Maria Alviano, Giulia Capitoli, Nicole Monza, Andrew Smith, Daniela Pilla, Alice Maggioni, Mariia Ivanova, Konstantinos Venetis and 8 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Vanna DentiProteomics and Metabolomics Unit, Department of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy.ORCID 0000-0001-6373-689X
Angela GrecoDepartment of Medicine and Surgery, Pathology, Center of Digital Medicine, University of Milano-Bicocca, Fondazione IRCCS San Gerardo dei Tintori, Via Cadore 48, 20900 Monza, Italy.
Antonio Maria AlvianoDepartment of Medicine and Surgery, Pathology, Center of Digital Medicine, University of Milano-Bicocca, Fondazione IRCCS San Gerardo dei Tintori, Via Cadore 48, 20900 Monza, Italy.ORCID 0009-0002-0686-6203
Giulia CapitoliBicocca Bioinformatics Biostatistics and Bioimaging Research Centre-B4, Department of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy.ORCID 0000-0002-8178-2440
Nicole MonzaProteomics and Metabolomics Unit, Department of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy.
Andrew SmithProteomics and Metabolomics Unit, Department of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy.ORCID 0000-0001-6530-6113
Daniela PillaDepartment of Medicine and Surgery, Pathology, Center of Digital Medicine, University of Milano-Bicocca, Fondazione IRCCS San Gerardo dei Tintori, Via Cadore 48, 20900 Monza, Italy.
Alice MaggioniDepartment of Medicine and Surgery, Pathology, Center of Digital Medicine, University of Milano-Bicocca, Fondazione IRCCS San Gerardo dei Tintori, Via Cadore 48, 20900 Monza, Italy.
Mariia IvanovaDepartment of Pathology and Laboratory Medicine, European Institute of Oncology IRCCS, 20141 Milan, Italy.ORCID 0000-0002-7636-1000
Konstantinos VenetisDepartment of Pathology and Laboratory Medicine, European Institute of Oncology IRCCS, 20141 Milan, Italy.
Fausto MaffiniDepartment of Pathology and Laboratory Medicine, European Institute of Oncology IRCCS, 20141 Milan, Italy.ORCID 0000-0002-4554-8956
Mattia GaranciniFondazione IRCCS San Gerardo dei Tintori, 20900 Monza, Italy.
Angela Ida PincelliFondazione IRCCS San Gerardo dei Tintori, 20900 Monza, Italy.
Stefania GalimbertiBicocca Bioinformatics Biostatistics and Bioimaging Research Centre-B4, Department of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy.ORCID 0000-0003-1504-7242
Fulvio MagniProteomics and Metabolomics Unit, Department of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy.ORCID 0000-0002-8663-0374
Nicola FuscoDepartment of Pathology and Laboratory Medicine, European Institute of Oncology IRCCS, 20141 Milan, Italy.ORCID 0000-0002-9101-9131
Vincenzo L'ImperioDepartment of Medicine and Surgery, Pathology, Center of Digital Medicine, University of Milano-Bicocca, Fondazione IRCCS San Gerardo dei Tintori, Via Cadore 48, 20900 Monza, Italy.ORCID 0000-0002-9284-2998
Fabio PagniDepartment of Medicine and Surgery, Pathology, Center of Digital Medicine, University of Milano-Bicocca, Fondazione IRCCS San Gerardo dei Tintori, Via Cadore 48, 20900 Monza, Italy.ORCID 0000-0001-9625-1637

Funding

Italian Ministry of the University MUR Dipartimenti di Eccellenza 2023-2027 IMPACT MEDICINE Project (IMPACT MEDICINE, l. 232/2016, art. 1, commi 314 - 337) Ricerca Finalizzata GR-2019-12368592National Plan for NRRP Complementary Investments (PNC), Directorial Decree n. 931 of 06-06-2022 - project n. PNC0000003 - AdvaNced Technologies for Human-centrEd Medicine (project acronym: ANTHEM) Ricerca Finalizzata GR-2019-12368592
6 · The paper itself

Abstract

Follicular-patterned thyroid neoplasms comprise a diverse group of lesions that pose significant challenges in terms of differential diagnosis based solely on morphologic and genetic features. Thus, the identification of easily testable biomarkers complementing microscopic and genetic analyses is a highly anticipated advancement that could improve diagnostic accuracy, particularly for noninvasive follicular thyroid neoplasms with papillary-like nuclear features (NIFTPs). These tumors exhibit considerable morphological and molecular heterogeneity, which may complicate their distinction from structurally similar neoplasms, especially when genetic analyses reveal shared genomic alterations (e.g.,

Indexed as

Adenocarcinoma, FollicularMutationProteomicsras ProteinsThyroid NeoplasmsAdultAgedBiomarkers, TumorFemaleHigh-Throughput Nucleotide SequencingHumansMaleMiddle AgedSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationBiomarkers, Tumorras ProteinsMALDI-MSINGSNIFTPproteomicsRAS mutationsthyroid neoplasms

Identifiers

PMID39684824
PMCPMC11641690

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.