Evidence map›Paper›PMID 39684800›Full record

ArticleInternational journal of molecular sciences2024

Calaspargase-Pegol-Mknl Combined with BCL-2 and MCL-1 Inhibition for Acute Myeloid Leukemia.

Dominique Bollino, Xinrong Ma, Kayla M Tighe, Andrea Casildo, Katharina Richard, Antonino Passaniti, Brandon Carter-Cooper, Erin T Strovel, Ashkan Emadi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Dominique BollinoDepartment of Medical Oncology, Cancer Institute, West Virginia University, Morgantown, WV 26506, USA.
Xinrong MaThe Biology Department, University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center, Baltimore, MD 21201, USA.
Kayla M TigheThe Biology Department, University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center, Baltimore, MD 21201, USA.
Andrea CasildoThe Biology Department, University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center, Baltimore, MD 21201, USA.
Katharina RichardThe Biology Department, University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center, Baltimore, MD 21201, USA.
Antonino PassanitiThe Biology Department, University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center, Baltimore, MD 21201, USA.
Brandon Carter-CooperThe Biology Department, University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center, Baltimore, MD 21201, USA.
Erin T StrovelDepartment of Pharmacology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Ashkan EmadiDepartment of Medical Oncology, Cancer Institute, West Virginia University, Morgantown, WV 26506, USA.ORCID 0000-0003-3769-3210

Funding

Servier Pharmacueticals unknown
6 · The paper itself

Abstract

Our previous studies have demonstrated that pegcrisantaspase (PegC), a long-acting

Indexed as

AsparaginaseLeukemia, Myeloid, AcuteMyeloid Cell Leukemia Sequence 1 ProteinProto-Oncogene Proteins c-bcl-2Xenograft Model Antitumor AssaysAnimalsApoptosisBridged Bicyclo Compounds, HeterocyclicCell Line, TumorDrug SynergismHumansMicePyrimidinesSulfonamidesThiophenesAsparaginaseBCL2 protein, humanBridged Bicyclo Compounds, HeterocyclicMCL1 protein, humanMyeloid Cell Leukemia Sequence 1 ProteinProto-Oncogene Proteins c-bcl-2PyrimidinesS63845SulfonamidesThiophenesvenetoclaxacute myeloid leukemiaasparaginaseBCL-2MCL-1

Identifiers

PMID39684800
PMCPMC11641566

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.