ReviewInternational journal of molecular sciences2024
Plasma Cells as the Key Players of IVF Failure? Unlocking the Enigma of Infertility and In Vitro Fertilization Failure in the Light of Uterine Inflammation.
Review in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The impact of CD138 plasma cell severity on IVF-ET outcomes in women with untreated chronic endometritis: a systematic review and meta-analysis.BMC pregnancy and childbirth · 2026Pooled it
- Chronic Endometritis and Endometrial Polyps in Female Infertility: Etiological Mechanisms, Diagnostic Insights, and Prognostic Implications.Journal of clinical medicine · 2026Review
- Diagnostic Accuracy of MUM1 (IRF4) Immunohistochemistry in Chronic Endometritis: A Systematic Review and Bayesian Meta-Analysis.Diagnostics (Basel, Switzerland) · 2026Review
- Role of CD138Biomedicines · 2025Review
- Integrating salpingoscopy and immunohistochemistry to improve tubal infertility diagnosis: a retrospective cohort study.Frontiers in reproductive health · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is an interplay between plasma cells, endometritis, and infertility, particularly in the context of in vitro fertilization (IVF) failure. This narrative literature review explains the pathophysiology of endometritis, detailing the involvement of various immune cells, cytokines, and chemokines in the regulation of inflammatory responses within the uterine endometrium. Here, we discuss the physiological role of plasma cells in immunity and their detection as markers of chronic endometritis, a disease associated with reproductive disorders. Our study also highlights the importance of CD138 immunohistochemical staining in the diagnosis of chronic endometritis, emphasizing the presence of plasma cells in endometrial tissue and its association with infertility and recurrent implantation failure. Of particular interest are the proposed diagnostic criteria for chronic endometritis based on the presence of plasma cells and studies that suggest a threshold for diagnosing this condition. We highlight the importance of examining the regenerative potential of endometrial stem cells in the treatment of infertility related to endometrial disorders.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.