ArticleInternational journal of molecular sciences2024
Sodium, Potassium-Adenosine Triphosphatase as a Potential Target of the Anti-Tuberculosis Agents, Clofazimine and Bedaquiline.
Khomotso Mmakola, Marissa Balmith, Helen Steel, Mohamed Said, Moliehi Potjo, Mieke van der Mescht, Nomsa Hlatshwayo, Pieter Meyer, Gregory Tintinger, Ronald Anderson and 1 more
Abstract read
In one paragraphArticle in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
11 authors.
Khomotso MmakolaDepartment of Immunology, Faculty of Health Sciences, University of Pretoria, Pretoria 0001, South Africa.ORCID 0000-0002-9383-2660 Marissa BalmithDepartment of Pharmacology, Faculty of Health Sciences, University of Pretoria, Pretoria 0084, South Africa.
Helen SteelDepartment of Immunology, Faculty of Health Sciences, University of Pretoria, Pretoria 0001, South Africa.ORCID 0000-0001-5899-4472 Mohamed SaidDepartment of Medical Microbiology, Faculty of Health Sciences, University of Pretoria, Pretoria 0001, South Africa.
Moliehi PotjoDepartment of Immunology, Faculty of Health Sciences, University of Pretoria, Pretoria 0001, South Africa.
Mieke van der MeschtDepartment of Immunology, Faculty of Health Sciences, University of Pretoria, Pretoria 0001, South Africa.
Nomsa HlatshwayoDepartment of Immunology, Faculty of Health Sciences, University of Pretoria, Pretoria 0001, South Africa.
Pieter MeyerDepartment of Immunology, Faculty of Health Sciences, University of Pretoria, Pretoria 0001, South Africa.ORCID 0000-0002-7318-1055 Gregory TintingerDepartment of Internal Medicine, Steve Biko Academic Hospital, Faculty of Health Sciences, University of Pretoria, Pretoria 0002, South Africa.
Ronald AndersonDepartment of Immunology, Faculty of Health Sciences, University of Pretoria, Pretoria 0001, South Africa.ORCID 0000-0002-5925-6452 Moloko CholoDepartment of Immunology, Faculty of Health Sciences, University of Pretoria, Pretoria 0001, South Africa.
Funding
National Health Laboratory Services Research Trust NHLSRT, 94648South African Medical Research Council Self Initiated Grant 2022 SIR 2022, MC Cholo
6 · The paper itselfAbstract
Multidrug-resistant tuberculosis (MDR-TB) patients are treated with a standardised, short World Health Organization (WHO) regimen which includes clofazimine (CFZ) and bedaquiline (BDQ) antibiotics. These two antibiotics lead to the development of QT prolongation in patients, inhibiting potassium (K
Indexed as
Antitubercular AgentsClofazimineDiarylquinolinesMolecular Docking SimulationMyocytes, CardiacSodium-Potassium-Exchanging ATPaseAdenosine TriphosphateAnimalsCell SurvivalRatsAdenosine TriphosphateAntitubercular AgentsbedaquilineClofazimineDiarylquinolinesSodium-Potassium-Exchanging ATPaseadenosine triphosphatebedaquilinecardiomyocytescellular viabilityclofaziminemultidrug-resistant tuberculosissodium, potassium-adenosine triphosphatase
Identifiers
PMID39684733
PMCPMC11640857
What OpenQuestion holds
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