Evidence map›Paper›PMID 39684707›Full record

ArticleInternational journal of molecular sciences2024

TRPM8's Role in the Shift Between Opioid and Cannabinoid Pathways in Electroacupuncture for Inflammatory Pain in Mice.

Dinh-Trong Pham, Rae-Mann Hsu, Mao-Feng Sun, Chien-Chen Huang, Yi-Hung Chen, Jaung-Geng Lin

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
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  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Dinh-Trong PhamGraduate Institute of Acupuncture Science, China Medical University, No. 91, Xueshi Road, North District, Taichung City 404328, Taiwan.ORCID 0009-0005-7488-2215
Rae-Mann HsuSchool of Chinese Medicine, China Medical University, No. 91, Xueshi Road, North District, Taichung City 404328, Taiwan.ORCID 0009-0008-8139-2478
Mao-Feng SunSchool of Chinese Medicine, China Medical University, No. 91, Xueshi Road, North District, Taichung City 404328, Taiwan.
Chien-Chen HuangDepartment of Chinese Medicine, An Nan Hospital, China Medical University, Tainan City 700, Taiwan.ORCID 0000-0003-0250-2170
Yi-Hung ChenGraduate Institute of Acupuncture Science, China Medical University, No. 91, Xueshi Road, North District, Taichung City 404328, Taiwan.ORCID 0000-0002-8946-7939
Jaung-Geng LinSchool of Chinese Medicine, China Medical University, No. 91, Xueshi Road, North District, Taichung City 404328, Taiwan.ORCID 0000-0002-3642-8047

Funding

China Medical University, Taiwan CMU110-MF-55Ministry of Science and Technology, Taiwan 110-2320-B-039 -023 -MY3Ministry of Science and Technology, Taiwan 111-2320-B-906 -001 -MY3Ministry of Science and Technology, Taiwan 112-2320-B-039-034-MY3
6 · The paper itself

Abstract

The TRPM8 channel, a temperature-sensitive ion channel, plays a crucial role in various physiological processes, particularly in the modulation of inflammation and nociception. Although electroacupuncture (EA) is a recognized analgesic treatment for pain conditions, its interaction with TRPM8 remains underexplored. This study aims to determine TRPM8's role in EA-induced analgesia using a murine model of inflammatory pain. Mechanical allodynia, evidenced by a reduced paw withdrawal threshold (PWT), was induced in both wild-type and

Indexed as

ElectroacupunctureInflammationTRPM Cation ChannelsAnalgesics, OpioidAnimalsCannabinoidsHyperalgesiaMaleMiceMice, Inbred C57BLMice, KnockoutNaloxoneNarcotic AntagonistsPainPain ManagementPiperidinesAM 251Analgesics, OpioidCannabinoidsNaloxoneNarcotic AntagonistsPiperidinesPyrazolesReceptor, Cannabinoid, CB1TRPM8 protein, mouseTRPM Cation Channelsanalgesiacomplete Freund’s adjuvantelectroacupunctureinflammatory painmechanical allodyniaTRPM8

Identifiers

PMID39684707
PMCPMC11641359

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.