Evidence map›Paper›PMID 39684589›Full record

ArticleInternational journal of molecular sciences2024

1,3-Dithiolane as a Privileged Scaffold in Bioactive Derivatives: Chiral Resolution and Assignment of Absolute Configuration.

Roberta Listro, Giacomo Rossino, Valeria Cavalloro, Daniela Rossi, Massimo Boiocchi, Marina Simona Robescu, Teodora Bavaro, Silvia Franchini, Claudia Sorbi, Marco De Amici and 2 more

Abstract read
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In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Roberta ListroDepartment of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100 Pavia, Italy.
Giacomo RossinoDepartment of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100 Pavia, Italy.ORCID 0000-0002-1008-5736
Valeria CavalloroDepartment of Earth and Environmental Sciences, University of Pavia, Via Sant'Epifanio 14, 27100 Pavia, Italy.ORCID 0000-0002-9759-5148
Daniela RossiDepartment of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100 Pavia, Italy.ORCID 0000-0002-2458-3728
Massimo BoiocchiCentro Grandi Strumenti, University of Pavia, Via Bassi 21, 27100 Pavia, Italy.ORCID 0000-0002-4991-145X
Marina Simona RobescuDepartment of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100 Pavia, Italy.ORCID 0000-0003-0914-5356
Teodora BavaroDepartment of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100 Pavia, Italy.ORCID 0000-0002-1286-2535
Silvia FranchiniDepartment of Life Sciences, University of Modena and Reggio Emilia, Via Campi 103, 41125 Modena, Italy.ORCID 0000-0002-6320-9712
Claudia SorbiDepartment of Life Sciences, University of Modena and Reggio Emilia, Via Campi 103, 41125 Modena, Italy.ORCID 0000-0001-6916-4933
Marco De AmiciDepartment of Pharmaceutical Sciences, University of Milan, Via Luigi Mangiagalli 25, 20133 Milan, Italy.ORCID 0000-0002-0236-0662
Pasquale LincianoDepartment of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100 Pavia, Italy.ORCID 0000-0003-0382-7479
Simona CollinaDepartment of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100 Pavia, Italy.ORCID 0000-0002-2954-7558

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The 1,3-dithiolane ring has been recently rehabilitated as a chemical scaffold in drug design. However, for derivatives that are substituted in position 4, the introduction of a chiral center on the heterocycle demands the separation and characterization of the stereoisomers. We report the first chiral resolution and absolute configuration (AC) assignment for (1,4-dithiaspiro[4.5]decan-2-yl)methanol (

Indexed as

Receptors, sigmaChromatography, High Pressure LiquidCrystallography, X-RayMolecular StructureStereoisomerismReceptors, sigma1,3-dithiolaneabsolute configuration assignmentchiral resolutionenantioselective chromatographyX-ray diffraction

Identifiers

PMID39684589
PMCPMC11641153

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.