Evidence map›Paper›PMID 39684558›Full record

ArticleInternational journal of molecular sciences2024

Effect of Low-Frequency, Low-Energy Pulsed Electromagnetic Fields in Neuronal and Microglial Cells Injured with Amyloid-Beta.

Stefania Merighi, Manuela Nigro, Alessia Travagli, Mercedes Fernandez, Fabrizio Vincenzi, Katia Varani, Silvia Pasquini, Pier Andrea Borea, Simona Salati, Ruggero Cadossi and 1 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Stefania MerighiDepartment of Translational Medicine, University of Ferrara, 44121 Ferrara, Italy.ORCID 0000-0003-0839-6671
Manuela NigroDepartment of Translational Medicine, University of Ferrara, 44121 Ferrara, Italy.
Alessia TravagliDepartment of Translational Medicine, University of Ferrara, 44121 Ferrara, Italy.
Mercedes FernandezDepartment of Translational Medicine, University of Ferrara, 44121 Ferrara, Italy.ORCID 0000-0003-1237-5275
Fabrizio VincenziDepartment of Translational Medicine, University of Ferrara, 44121 Ferrara, Italy.ORCID 0000-0002-5027-1699
Katia VaraniDepartment of Translational Medicine, University of Ferrara, 44121 Ferrara, Italy.ORCID 0000-0003-4562-1348
Silvia PasquiniDepartment of Chemical, Pharmaceutical and Agricultural Science, University of Ferrara, 44121 Ferrara, Italy.ORCID 0000-0001-9442-1428
Pier Andrea BoreaUniversity of Ferrara, 44121 Ferrara, Italy.
Simona SalatiIgea Clinical Biophysics, Medical Division, 41012 Carpi, Italy.ORCID 0000-0002-8072-1128
Ruggero CadossiIgea Clinical Biophysics, Medical Division, 41012 Carpi, Italy.
Stefania GessiDepartment of Translational Medicine, University of Ferrara, 44121 Ferrara, Italy.

Funding

IGEA SpA R/IGEA/Gessi/01/21
6 · The paper itself

Abstract

Alzheimer's disease (AD) is a neurodegenerative pathology covering about 70% of all cases of dementia. It is associated with neuroinflammation and neuronal cell death, which are involved in disease progression. There is a lack of effective therapies, and halting this process represents a therapeutic challenge. Data in the literature suggest several neuroprotective effects of low-frequency, low-energy pulsed electromagnetic fields (PEMFs) on biological systems, and clinical studies report that PEMF stimulation is safe and well tolerated. The aim of this work is to investigate the effects of PEMF exposure on oxidative stress and cell death in in vitro-injured cellular models of neurons and microglia. SH-SY5Y cells were stimulated by hydrogen peroxide (H

Indexed as

Amyloid beta-PeptidesElectromagnetic FieldsMicrogliaNeuronsOxidative StressAlzheimer DiseaseAnimalsCell DeathCell LineCell Line, TumorHumansHydrogen PeroxideMiceMitochondriaReactive Oxygen SpeciesAmyloid beta-PeptidesHydrogen PeroxideReactive Oxygen SpeciesAlzheimer’s diseaseAβ peptidecell deathlow-energy pulsed electromagnetic fieldslow-frequencymicroglianeuronsoxidative stress

Identifiers

PMID39684558
PMCPMC11641689

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.