Evidence map›Paper›PMID 39684522›Full record

ArticleInternational journal of molecular sciences2024

A Potential Use of Vidarabine: Alleviation of Functional Constipation Through Modulation of the Adenosine A2A Receptor-MLC Signaling Pathway and the Gut Microbiota.

Xiaoyu Gao, Kaifeng Guo, Shuangfeng Liu, Weixing Yang, Jun Sheng, Yang Tian, Lei Peng, Yan Zhao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Foods (Basel, Switzerland) · 2025
    Article
  4. Frontiers in pharmacology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xiaoyu GaoYunnan Key Laboratory of Precision Nutrition and Personalized Food Manufacturing, Yunnan Agricultural University, Kunming 650201, China.ORCID 0009-0003-1468-8184
Kaifeng GuoCollege of Food Science and Technology, Yunnan Agricultural University, Kunming 650201, China.
Shuangfeng LiuCollege of Food Science and Technology, Yunnan Agricultural University, Kunming 650201, China.
Weixing YangCollege of Food Science and Technology, Yunnan Agricultural University, Kunming 650201, China.
Jun ShengEngineering Research Center of Development and Utilization of Food and Drug Homologous Resources, Ministry of Education, Yunnan Agricultural University, Kunming 650201, China.
Yang TianYunnan Key Laboratory of Precision Nutrition and Personalized Food Manufacturing, Yunnan Agricultural University, Kunming 650201, China.
Lei PengCollege of Food Science and Technology, Yunnan Agricultural University, Kunming 650201, China.
Yan ZhaoDivision of Science and Technology, Yunnan Agricultural University, Kunming 650201, China.

Funding

Xingdian talent plan of Yunnan Province Young talents project, 2022-0255Yunnan Fundamental Research Projects 202401AT070217, 202401AT070216Yunnan Province-City Integration Project 202302AN360002
6 · The paper itself

Abstract

Vidarabine (VID) is an antiviral medication that is commonly utilized to treat conditions such as hand, foot, and mouth disease and herpes. Constipation is a prevalent complication of these diseases. Could VID treat these diseases by influencing defecation behavior? To date, no studies have been conducted on the potential of VID to relieve constipation. Therefore, a systematic investigation was conducted into the laxative effects and mechanisms of VID using loperamide-induced functional constipated mice. The findings indicate that the oral administration of VID promoted gastrointestinal peristalsis, improved fecal properties, facilitated defecation, and demonstrated a significant laxative effect on functional constipated mice. It has been demonstrated that VID may increase the water content of feces by regulating the expression of aquaporins (AQP3, AQP4, and

Indexed as

ConstipationGastrointestinal MicrobiomeReceptor, Adenosine A2ASignal TransductionAnimalsColonDefecationDisease Models, AnimalGastrointestinal MotilityLoperamideMaleMiceLoperamideReceptor, Adenosine A2Aadenine arabinosideadenosine A2A receptoraquaporinsgut microbiotaintestinal motilityMuribaculaceaeMuribaculumParasutterella

Identifiers

PMID39684522
PMCPMC11641518

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.