Evidence map›Paper›PMID 39684507›Full record

ArticleInternational journal of molecular sciences2024

The Neuroprotective Effect of the X Protein of Orthobornavirus Bornaense Type 1 in Amyotrophic Lateral Sclerosis.

Jeflie Tournezy, Claire Léger, Bernard Klonjkowski, Daniel Gonzalez-Dunia, Marion Szelechowski, André Garenne, Stéphane Mathis, Stéphanie Chevallier, Gwendal Le Masson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jeflie TournezyNeurocentre Magendie INSERM U1215, Université de Bordeaux, 33000 Bordeaux, France.ORCID 0009-0008-4597-7225
Claire LégerNeurocentre Magendie INSERM U1215, Université de Bordeaux, 33000 Bordeaux, France.
Bernard KlonjkowskiUMR 1161 Virologie, INRA, ANSES, Ecole Nationale Vétérinaire d'Alfort, 94700 Maisons-Alfort, France.ORCID 0000-0003-3372-0656
Daniel Gonzalez-DuniaInfinity (Toulouse Institute for Infectious and Inflammatory Diseases), INSERM, CNRS, Université de Toulouse, UPS, 31024 Toulouse, France.ORCID 0000-0002-2837-7120
Marion SzelechowskiInfinity (Toulouse Institute for Infectious and Inflammatory Diseases), INSERM, CNRS, Université de Toulouse, UPS, 31024 Toulouse, France.ORCID 0000-0002-2929-7413
André GarenneIMS Laboratory, UMR5218, CNRS, Bordeaux University, 33400 Talence, France.
Stéphane MathisNerve-Muscle Unit, ALS Center, Department of Neurology, University Hospital (CHU) of Bordeaux (Pellegrin Hospital), 33000 Bordeaux, France.
Stéphanie ChevallierNeurocentre Magendie INSERM U1215, Université de Bordeaux, 33000 Bordeaux, France.ORCID 0000-0002-3552-9137
Gwendal Le MassonNeurocentre Magendie INSERM U1215, Université de Bordeaux, 33000 Bordeaux, France.

Funding

Association Francaise contre les Myopathies trampoline grant 20219Association pour la recherche sur la Sclérose Latérale Amyotrophique Evaluation of the therapeutic potential of the Borna virus X protein and X-derived peptides in ALSFondation pour la Recherche Médicale Award Fabrice Le Mouaher 2020Rotary Club of Bergerac X protein and ALS
6 · The paper itself

Abstract

In amyotrophic lateral sclerosis (ALS), early mitochondrial dysfunction may contribute to progressive motor neuron loss. Remarkably, the ectopic expression of the Orthobornavirus bornaense type 1 (BoDV-1) X protein in mitochondria blocks apoptosis and protects neurons from degeneration. Therefore, this study examines the neuroprotective effects of X protein in an ALS mouse model. We first tested in vitro the effect of the X-derived peptide (PX3) on motoneurons primary cultures of SOD1

Indexed as

Amyotrophic Lateral SclerosisDisease Models, AnimalMotor NeuronsNeuroprotective AgentsAdenosine TriphosphateAnimalsHumansMiceMice, TransgenicViral ProteinsAdenosine TriphosphateNeuroprotective AgentsViral ProteinsALSBoDV-1mitochondriaSOD1G93A miceX protein

Identifiers

PMID39684507
PMCPMC11641280

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.