Evidence map›Paper›PMID 39684493›Full record

ArticleInternational journal of molecular sciences2024

Nidogen 2 Overexpression Promotes Hepatosteatosis and Atherosclerosis.

Ishita Kathuria, Aditi Prasad, Bal Krishan Sharma, Ravi Varma Aithabathula, Malvin Ofosu-Boateng, Maxwell A Gyamfi, Jianxiong Jiang, Frank Park, Udai P Singh, Bhupesh Singla

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. The Role ofBiology · 2025
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ishita KathuriaDepartment of Pharmaceutical Sciences, College of Pharmacy, The University of Tennessee Health Science Center, Memphis, TN 38103, USA.ORCID 0000-0001-8545-3890
Aditi PrasadDepartment of Pharmaceutical Sciences, College of Pharmacy, The University of Tennessee Health Science Center, Memphis, TN 38103, USA.
Bal Krishan SharmaCancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.ORCID 0000-0002-5962-645X
Ravi Varma AithabathulaDepartment of Pharmaceutical Sciences, College of Pharmacy, The University of Tennessee Health Science Center, Memphis, TN 38103, USA.
Malvin Ofosu-BoatengDepartment of Pharmaceutical Sciences, College of Pharmacy, The University of Tennessee Health Science Center, Memphis, TN 38103, USA.
Maxwell A GyamfiDepartment of Pharmaceutical Sciences, College of Pharmacy, The University of Tennessee Health Science Center, Memphis, TN 38103, USA.
Jianxiong JiangDepartment of Pharmaceutical Sciences, College of Pharmacy, The University of Tennessee Health Science Center, Memphis, TN 38103, USA.ORCID 0000-0003-3955-8928
Frank ParkDepartment of Pharmaceutical Sciences, College of Pharmacy, The University of Tennessee Health Science Center, Memphis, TN 38103, USA.ORCID 0000-0003-2324-2937
Udai P SinghDepartment of Pharmaceutical Sciences, College of Pharmacy, The University of Tennessee Health Science Center, Memphis, TN 38103, USA.ORCID 0000-0002-7048-4325
Bhupesh SinglaDepartment of Pharmaceutical Sciences, College of Pharmacy, The University of Tennessee Health Science Center, Memphis, TN 38103, USA.

Funding

Regulation of Lymphangiogenesis by Thrombospondin 1R00HL146954 · NHLBI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI SINGLA, BHUPESH · 2022 to 2024
$739k
Regulation of Lymphangiogenesis by Thrombospondin 1K99HL146954 · NHLBI · AUGUSTA UNIVERSITY · PI SINGLA, BHUPESH · 2020 to 2021
$232k
NHLBI NIH HHS K99 HL146954NHLBI NIH HHS R00 HL146954NIH HHS K99HL146954NIH HHS R00HL146954UTHSC College of Pharmacy Research Seed Grant 2024
6 · The paper itself

Abstract

Clinical and genetic studies strongly support a significant connection between nonalcoholic fatty liver disease (NAFLD) and atherosclerotic cardiovascular disease (ASCVD) and identify ASCVD as the primary cause of death in NAFLD patients. Understanding the molecular factors and mechanisms regulating these diseases is critical for developing novel therapies that target them simultaneously. Our preliminary immunoblotting experiments demonstrated elevated expression of nidogen 2 (NID2), a basement membrane glycoprotein, in human atherosclerotic vascular tissues and murine steatotic livers. Therefore, we investigated the role of NID2 in regulating hepatosteatosis and atherosclerosis utilizing Western diet-fed

Indexed as

AtherosclerosisAnimalsCalcium-Binding ProteinsDisease Models, AnimalFatty LiverHumansLiverMaleMembrane GlycoproteinsMiceMice, Inbred C57BLNon-alcoholic Fatty Liver DiseaseCalcium-Binding ProteinsMembrane GlycoproteinsnidogenAMPKatherosclerosishepatosteatosisNAFLDnidogen 2

Identifiers

PMID39684493
PMCPMC11641205

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.