Single Nucleotide Polymorphisms on Toll-like Receptor-4 and the Risk of Developing Skin Cancer.

Nabiha Yusuf, Noha Sharafeldin, Mohammad Saleem, Tom Callens, Ludwine M Messiaen, Craig A Elmets

Abstract read

In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Nabiha YusufDepartment of Dermatology, University of Alabama at Birmingham, 1670 University Boulevard VH566A, Birmingham, AL 35294, USA.ORCID 0000-0001-5730-0037

Noha SharafeldinDepartment of Hematology and Oncology, UAB Heersink School of Medicine, Birmingham, AL 35233, USA.

Mohammad SaleemDepartment of Dermatology, University of Alabama at Birmingham, 1670 University Boulevard VH566A, Birmingham, AL 35294, USA.

Tom CallensMedical Genomics Laboratory, Department of Clinical and Diagnostic Sciences, UAB School of Health Professions, Birmingham, AL 35233, USA.

Ludwine M MessiaenMedical Genomics Laboratory, Department of Clinical and Diagnostic Sciences, UAB School of Health Professions, Birmingham, AL 35233, USA.

Craig A ElmetsDepartment of Dermatology, University of Alabama at Birmingham, 1670 University Boulevard VH566A, Birmingham, AL 35294, USA.ORCID 0000-0001-7131-4697

Funding

Role of Trem1 in ultraviolet radiation-induced immune suppressionR01AI154842 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI XU, HUI, YUSUF, NABIHA · 2021 to 2025

$3.5M

NIAID NIH HHS R01 AI154842

6 · The paper itself

Abstract

Exposure to solar ultraviolet (UV) radiation is an established risk factor for skin cancer. Toll-like receptor-4 (TLR4)-mediated immune dysregulation has emerged as a key mechanism for the detrimental effects of acute and chronic UV exposure and skin cancer in mice. Single nucleotide polymorphisms (SNPs) on the

Indexed as

Genetic Predisposition to DiseasePolymorphism, Single NucleotideSkin NeoplasmsToll-Like Receptor 4AgedCase-Control StudiesCross-Sectional StudiesFemaleGenotypeHumansMaleMiddle AgedRisk FactorsTLR4 protein, humanToll-Like Receptor 4single nucleotide polymorphismsskin cancertoll-like receptor-4

Identifiers

PMID39684439

DOI10.3390/ijms252312728

PMCPMC11641301

What OpenQuestion holds

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LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.