Evidence map›Paper›PMID 39684435›Full record

ArticleInternational journal of molecular sciences2024

The DLEU2-miR-15a-16-1 Cluster Is a Determinant of Bone Microarchitecture and Strength in Postmenopausal Women and Mice.

Sjur Reppe, Janne Elin Reseland, Vid Prijatelj, Michael Prediger, Liebert Parreiras Nogueira, Tor Paaske Utheim, Fernando Rivadeneira, Kaare M Gautvik, Harish Kumar Datta

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sjur ReppeDepartment of Medical Biochemistry, Oslo University Hospital, 0450 Oslo, Norway.ORCID 0000-0002-4330-5379
Janne Elin ReselandDepartment of Biomaterials, Faculty of Dentistry, University of Oslo, 0317 Oslo, Norway.ORCID 0000-0001-5743-4297
Vid PrijateljDepartment of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, 3015 Rotterdam, The Netherlands.ORCID 0000-0002-9463-3962
Michael PredigerBlood Sciences, The Newcastle upon Tyne Hospitals NHS Foundation Trust, Royal Victoria Infirmary, Newcastle upon Tyne NE2 4HH, UK.
Liebert Parreiras NogueiraOral Research Laboratory, Faculty of Dentistry, University of Oslo, 0317 Oslo, Norway.ORCID 0000-0002-7767-464X
Tor Paaske UtheimDepartment of Medical Biochemistry, Oslo University Hospital, 0450 Oslo, Norway.
Fernando RivadeneiraDepartment of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, 3015 Rotterdam, The Netherlands.
Kaare M GautvikUnger-Vetlesen Institute, Lovisenberg Diaconal Hospital, 0456 Oslo, Norway.ORCID 0000-0002-3458-6113
Harish Kumar DattaBlood Sciences (Pathology), James Cook University Hospital, Middlesbrough TS4 3BW, UK.ORCID 0000-0002-4729-9340

Funding

Knowledge Transfer Account from Lovisenberg Diaconal Hospital Oslo, South-Eastern Norway Regional Health Authority (Oslo University Hospital) Project 29750104the European Union FP6 Project Osteogene FP6-502491
6 · The paper itself

Abstract

This study explores how select microRNAs (miRNAs) influence bone structure in humans and in transgenic mice. In trabecular bone biopsies from 84 postmenopausal women (healthy, osteopenic, and osteoporotic), we demonstrate that

Indexed as

Bone DensityMicroRNAsPostmenopauseAgedAnimalsBone and BonesBone RemodelingCancellous BoneFemaleHumansMiceMice, TransgenicMiddle AgedMultigene FamilyOsteoblastsQuantitative Trait LociMicroRNAsMIRN15 microRNA, humanboneDLEU2 geneeQTLmiRNAsosteoporosistransgenic mice

Identifiers

PMID39684435
PMCPMC11641114

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.