Evidence map›Paper›PMID 39684432›Full record

ArticleInternational journal of molecular sciences2024

Microglia-Impaired Phagocytosis Contributes to the Epileptogenesis in a Mouse Model of Dravet Syndrome.

I-Chun Chen, Shih-Yin Ho, Che-Wen Tsai, En-Li Chen, Horng-Huei Liou

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Dravet syndrome: novel insights intoFrontiers in neuroscience · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

I-Chun ChenDepartment of Pharmacology and Neurology, College of Medicine, National Taiwan University, Taipei 10051, Taiwan.ORCID 0000-0002-4136-9088
Shih-Yin HoGraduate Institute of Biomedical and Pharmaceutical Science, College of Medicine, Fu Jen Catholic University, New Taipei 24205, Taiwan.
Che-Wen TsaiDepartment of Pharmacology and Neurology, College of Medicine, National Taiwan University, Taipei 10051, Taiwan.
En-Li ChenDepartment of Pharmacology and Neurology, College of Medicine, National Taiwan University, Taipei 10051, Taiwan.
Horng-Huei LiouDepartment of Pharmacology and Neurology, College of Medicine, National Taiwan University, Taipei 10051, Taiwan.

Funding

Ministry of Science and Technology MOST 111-2314-B-002-251, 111-2314-B-030-011, 111-2314-B-030-010
6 · The paper itself

Abstract

Dravet syndrome (DS) is a genetic disorder caused by a deficit in the Nav1.1 channel, leading to drug-resistant epilepsy. The Nav1.1 channel plays a crucial role in microglial cell activation, and microglia are recognized as key mediators of seizures. In this study, we explored the role of microglia in DS-related epileptogenesis using a knock-in mouse model (

Indexed as

Disease Models, AnimalEpilepsies, MyoclonicMicrogliaNAV1.1 Voltage-Gated Sodium ChannelPhagocytosisAnimalsCytokinesLipopolysaccharidesMiceMice, Inbred C57BLCytokinesLipopolysaccharidesNAV1.1 Voltage-Gated Sodium ChannelScn1a protein, mouseDravet syndromemicrogliapatch-clampphagocytosisScn1a

Identifiers

PMID39684432
PMCPMC11641197

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.