Evidence map›Paper›PMID 39684412›Full record

ArticleInternational journal of molecular sciences2024

Genetic Manipulation of Caveolin-1 in a Transgenic Mouse Model of Aortic Root Aneurysm: Sex-Dependent Effects on Endothelial and Smooth Muscle Function.

Tala Curry-Koski, Brikena Gusek, Ross M Potter, T Bucky Jones, Raechel Dickman, Nathan Johnson, John N Stallone, Roshanak Rahimian, Johana Vallejo-Elias, Mitra Esfandiarei

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Tala Curry-KoskiBiomedical Sciences Program, College of Graduate Studies, Midwestern University, Glendale, AZ 85308, USA.ORCID 0000-0003-4262-1756
Brikena GusekBiomedical Sciences Program, College of Graduate Studies, Midwestern University, Glendale, AZ 85308, USA.
Ross M PotterDepartment of Physiology, College of Graduate Studies, Midwestern University, Glendale, AZ 85308, USA.
T Bucky JonesDepartment of Anatomy, College of Graduate Studies, Midwestern University, Glendale, AZ 85308, USA.
Raechel DickmanBiomedical Sciences Program, College of Graduate Studies, Midwestern University, Glendale, AZ 85308, USA.
Nathan JohnsonBiomedical Sciences Program, College of Graduate Studies, Midwestern University, Glendale, AZ 85308, USA.
John N StalloneDepartment of Veterinary Physiology & Pharmacology, Texas A&M University, College Station, TX 77843, USA.
Roshanak RahimianDepartment of Pharmaceutical Sciences, Thomas J. Long School of Pharmacy, University of the Pacific, Stockton, CA 95211, USA.ORCID 0000-0001-9803-0619
Johana Vallejo-EliasDepartment of Physiology, College of Graduate Studies, Midwestern University, Glendale, AZ 85308, USA.
Mitra EsfandiareiBiomedical Sciences Program, College of Graduate Studies, Midwestern University, Glendale, AZ 85308, USA.ORCID 0000-0003-3218-7781

Funding

The Marfan Foundation N/A
6 · The paper itself

Abstract

Marfan syndrome (MFS) is a systemic connective tissue disorder stemming from mutations in the gene encoding Fibrillin-1 (Fbn1), a key extracellular matrix glycoprotein. This condition manifests with various clinical features, the most critical of which is the formation of aortic root aneurysms. Reduced nitric oxide (NO) production due to diminished endothelial nitric oxide synthase (eNOS) activity has been linked to MFS aortic aneurysm pathology. Caveolin-1 (Cav1), a structural protein of plasma membrane caveolae, is known to inhibit eNOS activity, suggesting its involvement in MFS aneurysm progression by modulating NO levels. In this study, we examined the role of Cav1 in aortic smooth muscle and endothelial function, aortic wall elasticity, and wall strength in male and female MFS mice (

Indexed as

Aortic AneurysmCaveolin 1Marfan SyndromeAnimalsAortaAortic Root AneurysmDisease Models, AnimalEndothelium, VascularFemaleFibrillin-1MaleMiceMice, KnockoutMice, TransgenicMuscle, Smooth, VascularNitric OxideCav1 protein, mouseCaveolin 1Fibrillin-1Nitric OxideNitric Oxide Synthase Type IIIaortic aneurysmcaveolin-1endotheliumMarfan syndromesmooth muscle

Identifiers

PMID39684412
PMCPMC11641669

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.