Evidence map›Paper›PMID 39684405›Full record

ArticleInternational journal of molecular sciences2024

Natalia Petukhova, Anastasia Poluzerova, Dmitry Bug, Elena Nerubenko, Anna Kostareva, Uliana Tsoy, Renata Dmitrieva

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Cushing's Disease Manifestation inInternational journal of molecular sciences · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Natalia PetukhovaBioinformatics Research Center, Pavlov First Saint Petersburg Medical State University, 197022 Saint Petersburg, Russia.ORCID 0000-0001-6397-824X
Anastasia PoluzerovaSchool of Natural Sciences, Tyumen State University, 625003 Tyumen, Russia.ORCID 0009-0000-7392-0930
Dmitry BugBioinformatics Research Center, Pavlov First Saint Petersburg Medical State University, 197022 Saint Petersburg, Russia.ORCID 0000-0002-5849-1311
Elena NerubenkoAlmazov National Medical Research Centre, 197341 Saint Petersburg, Russia.ORCID 0009-0004-6629-8652
Anna KostarevaAlmazov National Medical Research Centre, 197341 Saint Petersburg, Russia.ORCID 0000-0002-9349-6257
Uliana TsoyAlmazov National Medical Research Centre, 197341 Saint Petersburg, Russia.
Renata DmitrievaAlmazov National Medical Research Centre, 197341 Saint Petersburg, Russia.ORCID 0000-0002-3073-7914

Funding

the Ministry of Science and Higher Education of the Russian Federa-tion Agreement No. 075-15-2022-301
6 · The paper itself

Abstract

The adenomas in Cushing's disease frequently exhibit mutations in exon 14, within a binding motif for the regulatory protein 14-3-3 located between the catalytic domain (DUB), responsible for ubiquitin hydrolysis, and the WW-like domain that mediates autoinhibition, resulting in constantly active USP8. The exact molecular mechanism of deubiquitinase activity disruption in Cushing's disease remains unclear. To address this, Sanger sequencing of

Indexed as

Molecular Dynamics SimulationMutationPituitary ACTH HypersecretionUbiquitin ThiolesteraseAdultEndopeptidasesEndosomal Sorting Complexes Required for TransportFemaleHumansMaleMiddle AgedProtein ConformationEndopeptidasesEndosomal Sorting Complexes Required for TransportUbiquitin ThiolesteraseUSP8 protein, human14-3-3 proteinCushing’s diseasedockingmolecular dynamicspituitary adenomaprotein modelingUSP8 mutationsUSP8 protein

Identifiers

PMID39684405
PMCPMC11641493

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.