Evidence map›Paper›PMID 39684363›Full record

ArticleInternational journal of molecular sciences2024

DNA Methylation Changes and Phenotypic Adaptations Induced Repeated Extreme Altitude Exposure at 8848 Meters.

Shixuan Zhang, La Yang, Zhuoma Duoji, Danzeng Qiangba, Xiaoxi Hu, Zeyu Jiang, Dandan Hou, Zixin Hu, Zhuoma Basang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Shixuan ZhangHigh Altitude Health Science Research Centre of Tibet University, Tibet University, 10 East Zangda Road, Lhasa 850000, China.
La YangHigh Altitude Health Science Research Centre of Tibet University, Tibet University, 10 East Zangda Road, Lhasa 850000, China.
Zhuoma DuojiHigh Altitude Health Science Research Centre of Tibet University, Tibet University, 10 East Zangda Road, Lhasa 850000, China.
Danzeng QiangbaHigh Altitude Health Science Research Centre of Tibet University, Tibet University, 10 East Zangda Road, Lhasa 850000, China.
Xiaoxi HuState Key Laboratory of Genetic Engineering, School of Life Sciences & Human Phenome Institute, Fudan University, Shanghai 200438, China.
Zeyu JiangState Key Laboratory of Genetic Engineering, School of Life Sciences & Human Phenome Institute, Fudan University, Shanghai 200438, China.
Dandan HouState Key Laboratory of Genetic Engineering, School of Life Sciences & Human Phenome Institute, Fudan University, Shanghai 200438, China.
Zixin HuArtificial Intelligence Innovation and Incubation Institute of Fudan University, Shanghai 200438, China.
Zhuoma BasangHigh Altitude Health Science Research Centre of Tibet University, Tibet University, 10 East Zangda Road, Lhasa 850000, China.

Funding

2019 School-level Cultivation Project of Tibet University ZDTSJH19-08Special Funds from the Central Finance to Support the Development of Local Universities [2018] No. 54; [2019] No. 1-19; [2020] No.79; [2021] No.1; (00060695/003)The Science and Technology Department of Tibet 08080002
6 · The paper itself

Abstract

Repeated extreme environmental training (RET) enhances adaptability and induces lasting methylation modifications. We recruited 64 participants from a high-altitude region (4700 m), including 32 volunteers with repeated high-altitude exposure, reaching up to 8848 m and as many as 11 exposures. By analyzing 741,489 CpG loci and 39 phenotypes, we identified significant changes in 13 CpG loci (R

Indexed as

Adaptation, PhysiologicalAltitudeCpG IslandsDNA MethylationPhenotypeAdultAltitude SicknessBayes TheoremFemaleHumansHypoxiaMaleMiddle Agedadaptive evolutionepigenetic modificationsextreme exposure

Identifiers

PMID39684363
PMCPMC11641581

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.