Evidence map›Paper›PMID 39684355›Full record

ArticleInternational journal of molecular sciences2024

Potentiation of NMDA Receptors by AT1 Angiotensin Receptor Activation in Layer V Pyramidal Neurons of the Rat Prefrontal Cortex.

Adrienn Hanuska, Polett Ribiczey, Erzsébet Kató, Zsolt Tamás Papp, Zoltán V Varga, Zoltán Giricz, Zsuzsanna E Tóth, Katalin Könczöl, Ákos Zsembery, Tibor Zelles and 2 more

Abstract read
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In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Trial
  2. Review
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Adrienn HanuskaDepartment of Oral Biology, Semmelweis University, H-1089 Budapest, Hungary.
Polett RibiczeyDepartment of Oral Biology, Semmelweis University, H-1089 Budapest, Hungary.
Erzsébet KatóDepartment of Pharmacology and Pharmacotherapy, Semmelweis University, H-1089 Budapest, Hungary.ORCID 0000-0001-5786-0405
Zsolt Tamás PappDepartment of Oral Biology, Semmelweis University, H-1089 Budapest, Hungary.
Zoltán V VargaDepartment of Pharmacology and Pharmacotherapy, Semmelweis University, H-1089 Budapest, Hungary.
Zoltán GiriczDepartment of Pharmacology and Pharmacotherapy, Semmelweis University, H-1089 Budapest, Hungary.ORCID 0000-0003-2036-8665
Zsuzsanna E TóthLaboratory of Neuroendocrinology and In Situ Hybridization, Department of Anatomy, Histology and Embryology, Semmelweis University, H-1094 Budapest, Hungary.ORCID 0000-0002-0628-1320
Katalin KönczölLaboratory of Neuroendocrinology and In Situ Hybridization, Department of Anatomy, Histology and Embryology, Semmelweis University, H-1094 Budapest, Hungary.
Ákos ZsemberyDepartment of Oral Biology, Semmelweis University, H-1089 Budapest, Hungary.
Tibor ZellesDepartment of Oral Biology, Semmelweis University, H-1089 Budapest, Hungary.
Laszlo G HarsingDepartment of Pharmacology and Pharmacotherapy, Semmelweis University, H-1089 Budapest, Hungary.
László KölesDepartment of Oral Biology, Semmelweis University, H-1089 Budapest, Hungary.

Funding

Ministry of Innovation and Technology of Hungary from the National Research, Development, and Innovation Fund TKP2021-EGA-23Ministry of Innovation and Technology of Hungary from the National Research, Development, and Innovation Fund TKP2021-EGA-25National Research, Development, and Innovation Office of Hungary NKFI K 146086National Research, Development, and Innovation Office of Hungary OTKA-K128875
6 · The paper itself

Abstract

NMDA receptors in the prefrontal cortex (PFC) play a crucial role in cognitive functions. Previous research has indicated that angiotensin II (Ang II) affects learning and memory. This study aimed to examine how Ang II impacts NMDA receptor activity in layer V pyramidal cells of the rat PFC. Whole-cell patch-clamp experiments were performed in pyramidal cells in brain slices of 9-12-day-old rats. NMDA (30 μM) induced inward currents. Ang II (0.001-1 µM) significantly enhanced NMDA currents in about 40% of pyramidal cells. This enhancement was reversed by the AT

Indexed as

Prefrontal CortexPyramidal CellsReceptor, Angiotensin, Type 1Receptors, N-Methyl-D-AspartateAngiotensin IIAngiotensin II Type 1 Receptor BlockersAnimalsBenzazepinesImidazolesMaleN-MethylaspartatePatch-Clamp TechniquesRatsRats, Sprague-DawleyReceptors, Dopamine D11-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazoleAngiotensin IIAngiotensin II Type 1 Receptor BlockersBenzazepinesImidazolesN-MethylaspartateReceptor, Angiotensin, Type 1Receptors, Dopamine D1Receptors, N-Methyl-D-AspartateSCH 23390AT1 angiotensin receptorD1 dopamine receptorneuromodulationNMDA receptorprefrontal cortexRAS

Identifiers

PMID39684355
PMCPMC11641273

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.