Evidence map›Paper›PMID 39684326›Full record

ReviewInternational journal of molecular sciences2024

Mast Cells in Allergic and Non-Allergic Upper Airways Diseases: Sentinel in the Watchtower.

Giovanni Costanzo, Marta Marchetti, Andrea Giovanni Ledda, Giada Sambugaro, Martina Bullita, Giovanni Paoletti, Enrico Heffler, Davide Firinu, Giulia Anna Maria Luigia Costanzo

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Giovanni CostanzoPersonalized Medicine, Asthma and Allergy, IRCCS Humanitas Research Hospital, 20089 Rozzano, Italy.ORCID 0009-0002-3267-0140
Marta MarchettiPersonalized Medicine, Asthma and Allergy, IRCCS Humanitas Research Hospital, 20089 Rozzano, Italy.
Andrea Giovanni LeddaDepartment of Medical Sciences and Public Health, University of Cagliari, 09124 Monserrato, Italy.ORCID 0009-0003-5456-2359
Giada SambugaroDepartment of Medical Sciences and Public Health, University of Cagliari, 09124 Monserrato, Italy.
Martina BullitaDepartment of Medical Sciences and Public Health, University of Cagliari, 09124 Monserrato, Italy.
Giovanni PaolettiPersonalized Medicine, Asthma and Allergy, IRCCS Humanitas Research Hospital, 20089 Rozzano, Italy.ORCID 0000-0003-3953-9225
Enrico HefflerPersonalized Medicine, Asthma and Allergy, IRCCS Humanitas Research Hospital, 20089 Rozzano, Italy.ORCID 0000-0002-0492-5663
Davide FirinuDepartment of Medical Sciences and Public Health, University of Cagliari, 09124 Monserrato, Italy.ORCID 0000-0002-5768-391X
Giulia Anna Maria Luigia CostanzoDepartment of Medical Sciences and Public Health, University of Cagliari, 09124 Monserrato, Italy.ORCID 0000-0003-2269-0439

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mast cells are immune system cells with the most disparate functions, but are also among the least understood. Mast cells are implicated in several known pathological processes, tissue homeostasis, and wound repair. However, they owe their notoriety to allergic diseases, of which they represent the effector cell par excellence. In both allergic and not upper airway pathologies, mast cells play a key role. Exploring the mechanisms through which these cells carry out their physiological and pathological function may help us give a new perspective on existing therapies and identify new ones. A focus will be placed on non-allergic rhinitis, a poorly recognized and often neglected condition with complex management, where the role of the mast cell is crucial in the pathogenetic, clinical, and prognostic aspects.

Indexed as

Mast CellsAnimalsHumansRespiratory Tract Diseasesallergymast cellsnasal polypsnon-allergic rhinitisrhinitisrhinosinusitis

Identifiers

PMID39684326
PMCPMC11641587

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.