Evidence map›Paper›PMID 39684318›Full record

ArticleInternational journal of molecular sciences2024

Combining Network Pharmacology and Transcriptomic Strategies to Explore the Pharmacological Mechanism of Total Ginsenoside Ginseng Root and Its Impact on Antidepressant Effects.

Weijia Chen, Pengli Guo, Lili Su, Xiangjuan Guo, Meiling Shi, Jianan Geng, Ying Zong, Yan Zhao, Rui Du, Zhongmei He

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Nutrients · 2026
    Review
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Weijia ChenCollege of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China.
Pengli GuoCollege of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China.
Lili SuCollege of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China.
Xiangjuan GuoCollege of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China.
Meiling ShiCollege of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China.
Jianan GengCollege of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China.
Ying ZongCollege of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China.
Yan ZhaoCollege of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China.ORCID 0000-0003-0704-7410
Rui DuCollege of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China.
Zhongmei HeCollege of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China.

Funding

Jilin Province Major Science and Technology Special Project 20220304001YY;20220304002YY
6 · The paper itself

Abstract

Depression is one of the most common neurological diseases, which imposes a substantial social and economic burden on modern society. The purpose of this study was to explore the mechanism of total ginsenoside ginseng root (TGGR) in the treatment of depression through a comprehensive strategy combining network pharmacology, transcriptomics, and in vivo experimental validation. The Traditional Chinese Medicine Systematic Pharmacology (TCMSP) database and literature were used to collect the main components and targets of TGGR. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were applied to explore the underlying mechanisms. In addition, the chronic unpredictable mild stress (CUMS)-induced C57BL/6 mouse model was used to evaluate the antidepressant activity of TGGR. The results showed that TGGR improved depression-like behavior in mice and increased the decrease in serum 5-hydroxytryptamine (5-HT) and brain-derived neurotrophic factor (BDNF) levels caused by CUMS. Combined network pharmacology and transcriptomic analysis showed that the AMP-activated kinase (AMPK) signaling pathway mainly enriched the core target. Immunohistochemistry, Western blotting, and reverse transcription quantitative polymerase chain reaction (RT-qPCR) were used to confirm whether TGGR exerts antidepressant effects by regulating this pathway. The results showed that TGGR has a regulatory impact on related proteins in the AMPK pathway, and the regulatory effect of TGGR on proteins was inhibited after the administration of related pathway inhibitors. In summary, total ginsenosides may regulate the AMPK signaling pathway and activate the sirtuin 1 (SIRT1) peroxisome proliferator-activated receptor-gamma coactivator 1-alpha (PGC-1α) pathway to have therapeutic effects on depression.

Indexed as

Antidepressive AgentsDepressionGinsenosidesNetwork PharmacologyPanaxPlant RootsTranscriptomeAMP-Activated Protein KinasesAnimalsBrain-Derived Neurotrophic FactorDisease Models, AnimalDrugs, Chinese HerbalGene Expression ProfilingMaleMiceMice, Inbred C57BLAMP-Activated Protein KinasesAntidepressive AgentsBrain-Derived Neurotrophic FactorDrugs, Chinese HerbalGinsenosidesPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPpargc1a protein, mouseSerotoninSirtuin 1AMPK-SIRT1-PGC-1α pathwaydepressionnetwork pharmacologyTGGRtranscriptome sequencing

Identifiers

PMID39684318
PMCPMC11640795

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.