Evidence map›Paper›PMID 39684312›Full record

Observational studyInternational journal of molecular sciences2024

An Analysis of the Digestive and Reproductive Tract Microbiota in Infertile Women with Obesity.

Jose Bellver, Marta Gonzalez-Monfort, Sandra González, Bruno Toson, Elena Labarta, Gemma Castillón, Giulia Mariani, Carmina Vidal, Juan Giles, Fabio Cruz and 9 more

Abstract readMulticenter StudyObservational Study
In one paragraph

Observational study in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Endometrial Microbiome and Reproductive Receptivity: Diverse Perspectives.International journal of molecular sciences · 2025
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Jose BellverIVIRMA Valencia, Pl. de la Policia Local, 3, 46015 Valencia, Spain.
Marta Gonzalez-MonfortCarlos Simon Foundation-INCLIVA Health Research Institute, Ronda Narcis Monturiol Estarriol, 11C, 46980 Paterna, Valencia, Spain.
Sandra GonzálezIVIRMA Bilbao, Landabarri Bidea, 3, 48940 Leioa, Biscay, Spain.
Bruno TosonCarlos Simon Foundation-INCLIVA Health Research Institute, Ronda Narcis Monturiol Estarriol, 11C, 46980 Paterna, Valencia, Spain.
Elena LabartaIVIRMA Valencia, Pl. de la Policia Local, 3, 46015 Valencia, Spain.ORCID 0000-0002-3048-9447
Gemma CastillónIVIRMA Barcelona, Carrer Mallorca, 45, 08029 Barcelona, Spain.
Giulia MarianiIVIRMA Valencia, Pl. de la Policia Local, 3, 46015 Valencia, Spain.
Carmina VidalIVIRMA Valencia, Pl. de la Policia Local, 3, 46015 Valencia, Spain.ORCID 0000-0001-8533-4509
Juan GilesIVIRMA Valencia, Pl. de la Policia Local, 3, 46015 Valencia, Spain.
Fabio CruzIVIRMA Valencia, Pl. de la Policia Local, 3, 46015 Valencia, Spain.
Agustin BallesterosIVIRMA Barcelona, Carrer Mallorca, 45, 08029 Barcelona, Spain.
Marcos FerrandoIVIRMA Bilbao, Landabarri Bidea, 3, 48940 Leioa, Biscay, Spain.
Juan Antonio García-VelascoIVIRMA Madrid, Av. del Talgo, 68, 28023 Madrid, Spain.ORCID 0000-0003-1005-8727
Diana ValbuenaIgenomix R&D, Ronda Narcis Monturiol Estarriol, 11B, 46980 Paterna, Valencia, Spain.ORCID 0000-0002-0742-3669
Felipe VilellaCarlos Simon Foundation-INCLIVA Health Research Institute, Ronda Narcis Monturiol Estarriol, 11C, 46980 Paterna, Valencia, Spain.
Marcos Parras-MoltoCarlos Simon Foundation-INCLIVA Health Research Institute, Ronda Narcis Monturiol Estarriol, 11C, 46980 Paterna, Valencia, Spain.
Esther Tercero-AtenciaCarlos Simon Foundation-INCLIVA Health Research Institute, Ronda Narcis Monturiol Estarriol, 11C, 46980 Paterna, Valencia, Spain.
Carlos SimonDepartment of Pediatrics, Obstetrics and Gynecology, University of Valencia, Av. de Blasco Ibáñez, 15, 46010 Valencia, Spain.
Inmaculada MorenoCarlos Simon Foundation-INCLIVA Health Research Institute, Ronda Narcis Monturiol Estarriol, 11C, 46980 Paterna, Valencia, Spain.

Funding

Agencia Estatal de Investigación RTI2018-094946-B-I00European Union GA101080219Generalitat Valenciana GRISOLIAP/2021/176Generalitat Valenciana INVEST/2022/478Instituto de Salud Carlos III PI21/00235Instituto de Salud Carlos III PI21/00528
6 · The paper itself

Abstract

Previous studies have linked the microbiome of distinct body habitats to obesity and infertility; however, the often-divergent results observed have left the role of the so-called "second genome" in obese infertile patients incompletely explored. Here, we present a prospective observational multicenter study of oral, gut, endometrial, and vaginal microbiota of infertile patients classified according to BMI. Patients collected saliva/fecal samples, while vaginal/endometrial fluid samples were collected in the clinic. Total bacterial DNA was extracted, and microbiota profiles were analyzed by 16S rRNA gene sequencing. Our results showed no differences in the Bacteroidetes/Firmicutes ratio (proposed obesity hallmark) in the gut microbiota between patients with obesity and normal weight; however, a tendency for higher levels of genera such as

Indexed as

BacteriaEndometriumGastrointestinal MicrobiomeInfertility, FemaleObesityVaginaAdultFecesFemaleHumansMicrobiotaProspective StudiesRNA, Ribosomal, 16SSalivaRNA, Ribosomal, 16Sendometriumfemale infertilitygut microbiotaobesityreproductive tract microbiotaStreptococcus

Identifiers

PMID39684312
PMCPMC11641297

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.