Evidence map›Paper›PMID 39684311›Full record

ArticleInternational journal of molecular sciences2024

Transcriptome Analysis of Fibroblasts in Hypoxia-Induced Vascular Remodeling: Functional Roles of CD26/DPP4.

Yuri Suzuki, Takeshi Kawasaki, Koichiro Tatsumi, Tadasu Okaya, Shun Sato, Ayako Shimada, Tomoko Misawa, Ryo Hatano, Chikao Morimoto, Yoshitoshi Kasuya and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Vascular Remodeling: The Multicellular Mechanisms of Pulmonary Hypertension.International journal of molecular sciences · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yuri SuzukiDepartment of Respirology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.ORCID 0000-0002-3006-5556
Takeshi KawasakiDepartment of Respirology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.ORCID 0000-0002-1468-172X
Koichiro TatsumiDepartment of Respirology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
Tadasu OkayaDepartment of Respirology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.ORCID 0000-0002-6724-2608
Shun SatoDepartment of Respirology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.ORCID 0009-0003-8730-4348
Ayako ShimadaDepartment of Respirology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
Tomoko MisawaDepartment of Respirology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
Ryo HatanoDepartment of Therapy Development and Innovation for Immune disorders and Cancers, Graduate School of Medicine, Juntendo University, Tokyo 113-8421, Japan.ORCID 0000-0002-2727-7275
Chikao MorimotoDepartment of Therapy Development and Innovation for Immune disorders and Cancers, Graduate School of Medicine, Juntendo University, Tokyo 113-8421, Japan.
Yoshitoshi KasuyaDepartment of Respirology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.ORCID 0000-0003-0614-5836
Yoshinori HasegawaDepartment of Applied Genomics, Kazusa DNA Research Institute, Chiba 292-0818, Japan.
Osamu OharaDepartment of Applied Genomics, Kazusa DNA Research Institute, Chiba 292-0818, Japan.ORCID 0000-0002-3328-9571
Takuji SuzukiDepartment of Respirology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.

Funding

AMED 223fa627003hAMED-CREST JP21gm1210003, JP23gm1810009GSK Japan Research Grant 2019 A-5Initiative for Realizing Diversity in the Research Environment; and a research grant from the In-tractable Respiratory Diseases and Pulmonary Hypertension Research Group, Ministry of Health, Labor and Welfare, Japan 20FC1027, 23FC1031JSPS KAKENHI 19K17663, 22K16163, 22H03076, 24K19102Therapeutics Research Initiative Grant from Chiba University School of Medicine 2019-G6
6 · The paper itself

Abstract

In hypoxic pulmonary hypertension (PH), pulmonary vascular remodeling is characterized by the emergence of activated adventitial fibroblasts, leading to medial smooth muscle hyperplasia. Previous studies have suggested that CD26/dipeptidyl peptidase-4 (DPP4) plays a crucial role in the pathobiological processes in lung diseases. However, its role in pulmonary fibroblasts in hypoxic PH remains unknown. Therefore, we aimed to clarify the mechanistic role of CD26/DPP4 in lung fibroblasts in hypoxic PH.

Indexed as

Dipeptidyl Peptidase 4FibroblastsGene Expression ProfilingHypoxiaMice, KnockoutVascular RemodelingAnimalsCells, CulturedHumansHypertension, PulmonaryLungMaleMiceMice, Inbred C57BLTranscriptomeTransforming Growth Factor betaDipeptidyl Peptidase 4DPP4 protein, humanDpp4 protein, mouseTransforming Growth Factor betaCD26dipeptidyl peptidase-4DPP4fibroblasthypoxiaTGFβvascular remodeling

Identifiers

PMID39684311
PMCPMC11640941

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.