Evidence map›Paper›PMID 39684307›Full record

ReviewInternational journal of molecular sciences2024

Advances in Tumor-Infiltrating Lymphocyte (TIL) as a Prognostic Factor and for Treating Invasive Cutaneous Melanoma.

Gabriel Alves Freiria de Oliveira, Daniel Arcuschin de Oliveira, Melissa Yoshimi Sakamoto Maeda Nisimoto, Rafael Rubinho, Heitor Carvalho Gomes, Luciana Cavalheiro Marti, Renato Santos de Oliveira Filho

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Cancer Immunotherapy-An Overview.Cancer treatment and research · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Gabriel Alves Freiria de OliveiraMelanoma and Skin Tumors Sector, Plastic Surgery Discipline, Escola Paulista de Medicina/Universidade Federal de São Paulo (EPM/UNIFESP), Rua Botucatu, 740, São Paulo 04023-062, SP, Brazil.
Daniel Arcuschin de OliveiraMelanoma and Skin Tumors Sector, Plastic Surgery Discipline, Escola Paulista de Medicina/Universidade Federal de São Paulo (EPM/UNIFESP), Rua Botucatu, 740, São Paulo 04023-062, SP, Brazil.ORCID 0000-0003-0591-041X
Melissa Yoshimi Sakamoto Maeda NisimotoMelanoma and Skin Tumors Sector, Plastic Surgery Discipline, Escola Paulista de Medicina/Universidade Federal de São Paulo (EPM/UNIFESP), Rua Botucatu, 740, São Paulo 04023-062, SP, Brazil.
Rafael RubinhoDepartment of Dermatology, Universidade Santo Amaro, Rua Isabel Schmidt, 349, Santo Amaro, São Paulo 04743-030, SP, Brazil.
Heitor Carvalho GomesMelanoma and Skin Tumors Sector, Plastic Surgery Discipline, Escola Paulista de Medicina/Universidade Federal de São Paulo (EPM/UNIFESP), Rua Botucatu, 740, São Paulo 04023-062, SP, Brazil.
Luciana Cavalheiro MartiDepartment of Experimental Research, Hospital Israelita Albert Einstein, Rua Comendador Elias Jafet, 755, Morumbi, São Paulo 05653-000, SP, Brazil.ORCID 0000-0002-3890-0827
Renato Santos de Oliveira FilhoMelanoma and Skin Tumors Sector, Plastic Surgery Discipline, Escola Paulista de Medicina/Universidade Federal de São Paulo (EPM/UNIFESP), Rua Botucatu, 740, São Paulo 04023-062, SP, Brazil.ORCID 0000-0002-7464-973X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Invasive cutaneous melanoma is responsible for about 5% of skin tumors yet is liable for nearly 70% of skin cancer-related deaths. Despite notable advancements over the past decade, including immunotherapies and targeted treatments, more than half of invasive melanoma patients ultimately succumb to the disease due to therapeutic resistance. To overcome this obstacle, strategies such as combining immunotherapies with targeted drugs or adding epigenetic therapies have been investigated. Tumor-infiltrating lymphocytes (TILs) therapy has emerged as a promising option for patients whose disease continues to progress despite standard treatments. This article aims to introduce TIL therapy and review recent outcomes in melanoma prognosis in its application for melanoma management.

Indexed as

Cutaneous Malignant MelanomaLymphocytes, Tumor-InfiltratingSkin NeoplasmsHumansImmunotherapyMelanomaNeoplasm InvasivenessPrognosiscutaneous melanomamelanomametastatic melanomatumor-infiltrating lymphocytes (TILs)

Identifiers

PMID39684307
PMCPMC11641307

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.