Evidence map›Paper›PMID 39684291›Full record

ArticleInternational journal of molecular sciences2024

Somatic Recombination Between an Ancient and a Recent

Rainer Hubmann, Martin Hilgarth, Tamara Löwenstern, Andrea Lienhard, Filip Sima, Manuel Reisinger, Claudia Hobel-Kleisch, Edit Porpaczy, Torsten Haferlach, Gregor Hoermann and 6 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Rainer HubmannDepartment of Internal Medicine I, Division of Hematology & Hemostaseology, Medical University of Vienna, 1090 Vienna, Austria.
Martin HilgarthDepartment of Internal Medicine I, Division of Hematology & Hemostaseology, Medical University of Vienna, 1090 Vienna, Austria.
Tamara LöwensternInstitute of Medical Genetics, Center for Pathobiochemistry and Genetics, Medical University of Vienna, 1090 Vienna, Austria.ORCID 0009-0006-9196-2097
Andrea LienhardAustrian Red Cross, Blood Service for Vienna, Lower Austria and Burgenland, 1040 Vienna, Austria.
Filip SimaAustrian Red Cross, Blood Service for Vienna, Lower Austria and Burgenland, 1040 Vienna, Austria.
Manuel ReisingerAustrian Red Cross, Blood Service for Vienna, Lower Austria and Burgenland, 1040 Vienna, Austria.
Claudia Hobel-KleischAustrian Red Cross, Blood Service for Vienna, Lower Austria and Burgenland, 1040 Vienna, Austria.
Edit PorpaczyDepartment of Internal Medicine I, Division of Hematology & Hemostaseology, Medical University of Vienna, 1090 Vienna, Austria.ORCID 0000-0001-7706-449X
Torsten HaferlachMLL Munich Leukemia Laboratory, 81377 Munich, Germany.
Gregor HoermannMLL Munich Leukemia Laboratory, 81377 Munich, Germany.ORCID 0000-0002-7374-4380
Franco LacconeInstitute of Medical Genetics, Center for Pathobiochemistry and Genetics, Medical University of Vienna, 1090 Vienna, Austria.ORCID 0000-0001-9466-6441
Christof JungbauerAustrian Red Cross, Blood Service for Vienna, Lower Austria and Burgenland, 1040 Vienna, Austria.
Peter ValentDepartment of Internal Medicine I, Division of Hematology & Hemostaseology, Medical University of Vienna, 1090 Vienna, Austria.ORCID 0000-0003-0456-5095
Philipp B StaberDepartment of Internal Medicine I, Division of Hematology & Hemostaseology, Medical University of Vienna, 1090 Vienna, Austria.
Medhat ShehataDepartment of Internal Medicine I, Division of Hematology & Hemostaseology, Medical University of Vienna, 1090 Vienna, Austria.
Ulrich JägerDepartment of Internal Medicine I, Division of Hematology & Hemostaseology, Medical University of Vienna, 1090 Vienna, Austria.ORCID 0000-0001-9826-1062

Funding

CCC Initiative Krebsforschung UE71104037Fellinger Krebsforschung FEKF2022
6 · The paper itself

Abstract

Constitutively active NOTCH2 signaling is a hallmark in chronic lymphocytic leukemia (CLL). The precise underlying defect remains obscure. Here we show that the mRNA sequence coding for the NOTCH2 negative regulatory region (NRR) is consistently deleted in CLL cells. The most common

Indexed as

Leukemia, Lymphocytic, Chronic, B-CellReceptor, Notch2Gain of Function MutationHumansMalePhenotypePhylogenyPolymorphism, Single NucleotideRecombination, GeneticNOTCH2 protein, humanReceptor, Notch2CLLevolutiongain of functionhaplotypesNOTCH2somatic recombination

Identifiers

PMID39684291
PMCPMC11641350

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.