Evidence map›Paper›PMID 39684289›Full record

ArticleInternational journal of molecular sciences2024

Viral-Porphyrin Combo: Photodynamic and Oncolytic Viral Therapy for Potent Glioblastoma Treatment.

Alina S Nazarenko, Alena O Shkirdova, Ekaterina A Orlova, Yulia K Biryukova, Mikhail F Vorovitch, Nadezhda M Kolyasnikova, Aydar A Ishmukhametov, Vladimir S Tyurin, Ilya A Zamilatskov

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Current Status and Evolution of Immunotherapy in Glioma Management.International journal of medical sciences · 2026
    Review
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Alina S NazarenkoChumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences (Institute of Poliomyelitis), 108819 Moscow, Russia.
Alena O ShkirdovaFrumkin Institute of Physical Chemistry and Electrochemistry, Russian Academy of Sciences, 119071 Moscow, Russia.
Ekaterina A OrlovaChumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences (Institute of Poliomyelitis), 108819 Moscow, Russia.
Yulia K BiryukovaChumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences (Institute of Poliomyelitis), 108819 Moscow, Russia.ORCID 0000-0002-5804-4001
Mikhail F VorovitchChumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences (Institute of Poliomyelitis), 108819 Moscow, Russia.ORCID 0000-0002-7367-6357
Nadezhda M KolyasnikovaChumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences (Institute of Poliomyelitis), 108819 Moscow, Russia.ORCID 0000-0002-9934-2582
Aydar A IshmukhametovChumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences (Institute of Poliomyelitis), 108819 Moscow, Russia.
Vladimir S TyurinFrumkin Institute of Physical Chemistry and Electrochemistry, Russian Academy of Sciences, 119071 Moscow, Russia.ORCID 0000-0002-8663-2935
Ilya A ZamilatskovChair of Chemistry, The Institute of Pharmacy, Sechenov First Moscow State Medical University (Sechenov University), 119571 Moscow, Russia.ORCID 0000-0003-0313-6264

Funding

The Ministry of Education and Science 122011300052-1The Ministry of Education and Science FNZG-2024-0003
6 · The paper itself

Abstract

Combined viral and photodynamic therapy for oncological diseases has great potential to treat aggressive tumors such as glioblastomas. A conjugate of vesicular stomatitis virus (VSV) with protoporphyrin IX was prepared, and its oncolytic effects were studied and compared to the effects of the individual components. The VSV showed an oncolytic effect on glioblastoma cell lines T98G and LN229 at a virus titer of 10

Indexed as

GlioblastomaOncolytic VirotherapyPhotochemotherapyPhotosensitizing AgentsProtoporphyrinsBrain NeoplasmsCell Line, TumorCombined Modality TherapyHumansOncolytic VirusesPorphyrinsVesiculovirusPhotosensitizing AgentsPorphyrinsprotoporphyrin IXProtoporphyrinscombination therapyglioblastomaphotodynamic therapyporphyrintargeted deliverytumorvesicular stomatitis virusviral therapy

Identifiers

PMID39684289
PMCPMC11640982

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.