Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
7 authors.
Nicolas MontalbettiRenal-Electrolyte Division, Department of Medicine, University of Pittsburgh, Pittsburg, PA 15261, USA.ORCID 0000-0003-2897-9540
Guadalupe Manrique-MaldonadoRenal-Electrolyte Division, Department of Medicine, University of Pittsburgh, Pittsburg, PA 15261, USA.ORCID 0000-0002-2191-9193
Youko IkedaRenal-Electrolyte Division, Department of Medicine, University of Pittsburgh, Pittsburg, PA 15261, USA.ORCID 0000-0001-9774-1523
Marianela DalghiRenal-Electrolyte Division, Department of Medicine, University of Pittsburgh, Pittsburg, PA 15261, USA.
Anthony KanaiRenal-Electrolyte Division, Department of Medicine, University of Pittsburgh, Pittsburg, PA 15261, USA.
Gerard ApodacaRenal-Electrolyte Division, Department of Medicine, University of Pittsburgh, Pittsburg, PA 15261, USA.
Marcelo D CarattinoRenal-Electrolyte Division, Department of Medicine, University of Pittsburgh, Pittsburg, PA 15261, USA.ORCID 0000-0003-1901-1618
Funding
Resource Development CoreU54DK137329 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Thomas R Kleyman · 2023 to 2026
$4.8M
ENaC regulation and its role in blood pressure homeostasisR01HL147818 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Annet Kirabo, Thomas R Kleyman · 2019 to 2026
$4.6M
Role of AJC in umbrella cell function and dysfunctionR01DK129473 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI APODACA, GERARD L · 2021 to 2025
$3.2M
Role of PIEZO Channels in Bladder Function and DysfunctionR01DK119183 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI APODACA, GERARD L, CARATTINO, MARCELO DANIEL · 2019 to 2023
$3.0M
Role of acid-sensing ion channels in bladder sensory signalingR01DK134431 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CARATTINO, MARCELO DANIEL · 2023 to 2025
$941k
Leica Stellaris Confocal for Kidney Imaging CoreS10OD028596 · OD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI APODACA, GERARD L · 2021 to 2021
$596k
National Institute of Health 1S10OD028596NHLBI NIH HHS R01 HL147818NIDDK NIH HHS R01 DK119183NIDDK NIH HHS R01 DK129473NIDDK NIH HHS R01 DK134431NIDDK NIH HHS U54 DK137329NIH HHS 1R01DK119183-05A1NIH HHS 1R01DK129473-03A1NIH HHS 1R01DK134431-01A1NIH HHS 1U54DK137329-01A1NIH HHS S10 OD028596
6 · The paper itself
Abstract
Sensitization of primary afferents is essential for the development of pain, but the molecular events involved in this process and its reversal are poorly defined. Recent studies revealed that acid-sensing ion channels (ASICs) control the excitability of nociceptors in the urinary bladder. Using genetic and pharmacological tools we show that ASICs are functionally coupled with voltage-gated Ca
Indexed as
Acid Sensing Ion ChannelsMice, KnockoutUrinary BladderVisceral PainAnimalsCyclophosphamideCystitisHyperalgesiaMaleMiceMice, Inbred C57BLNociceptorsSensory Receptor CellsAcid Sensing Ion ChannelsASIC3 protein, mouseCyclophosphamideacid-sensing ion channelschemical cystitissensory neuronsurinary bladdervisceral pain
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Expression of Acid-Sensing Ion Channel 3 in Afferents Averts Long-Term Sensitization and the Development of Visceral Pain. · full record | OpenQuestion