Evidence map›Paper›PMID 39684208›Full record

ArticleInternational journal of molecular sciences2024

Improved Kaempferol Solubility via Heptakis-O-(2-hydroxypropyl)-β-cyclodextrin Complexation: A Combined Spectroscopic and Theoretical Study.

Dongxu Han, Zhongbao Han, Liyan Liu, Shigang Xin, Zhan Yu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Kaempferol-A Natural Drug for Rheumatoid Arthritis.Chinese journal of integrative medicine · 2025
    Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Dongxu HanSchool of Chemistry and Chemical Engineering, Shenyang Normal University, Shenyang 110034, China.
Zhongbao HanSchool of Chemistry and Chemical Engineering, Shenyang Normal University, Shenyang 110034, China.ORCID 0009-0000-9089-2564
Liyan LiuSchool of Chemistry and Chemical Engineering, Shenyang Normal University, Shenyang 110034, China.
Shigang XinExperimental Teaching Center, Shenyang Normal University, Shenyang 110034, China.
Zhan YuSchool of Chemistry and Chemical Engineering, Shenyang Normal University, Shenyang 110034, China.ORCID 0000-0002-6538-2199

Funding

Fundamental Research Funds for the Universities of Liaoning Province JYTMS20231697, LJ212410166040, SYNU2024027National Natural Science Foundation of China 22404116Research Start-up Grant of SYNU BS202422
6 · The paper itself

Abstract

Four cyclodextrins (CDs) including heptakis-O-(2-hydroxypropyl)-β-cyclodextrin (HP-β-CD), heptakis-O-(2,6-di-O-methyl)-β-cyclodextrin (DM-β-CD), β-cyclodextrin (β-CD), and γ-cyclodextrin (γ-CD) were evaluated for their ability to enhance the aqueous solubility of kaempferol (Kae). Phase solubility studies indicated that these four CDs can form 1:1 type complexes with Kae and that HP-β-CD demonstrated the most significant solubilizing effect on Kae. Among the CDs tested, HP-β-CD demonstrated the most significant solubilizing effect on Kae. With an HP-β-CD concentration of 5.00 × 10

Indexed as

2-Hydroxypropyl-beta-cyclodextrinbeta-CyclodextrinsKaempferolsSolubilityHydrogen Bonding2-Hydroxypropyl-beta-cyclodextrinbeta-CyclodextrinskaempferolKaempferolsHP-β-CDkaempferolmolecular dynamicsphase solubilityPM7

Identifiers

PMID39684208
PMCPMC11641311

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.