Evidence map›Paper›PMID 39683944›Full record

ArticleMolecules (Basel, Switzerland)2024

Addressing the Evolution of Cardenolide Formation in Iridoid-Synthesizing Plants: Site-Directed Mutagenesis of PRISEs (Progesterone-5β-Reductase/Iridoid Synthase-like Enzymes) of Plantago Species.

Maja Dorfner, Jan Klein, Katharina Senkleiter, Harald Lanig, Wolfgang Kreis, Jennifer Munkert

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Maja DorfnerFriedrich-Alexander-Universität Erlangen-Nürnberg, Department of Biology, Pharmaceutical Biology, Staudtstraße 5, 91058 Erlangen, Germany.
Jan KleinDepartment of Plant Physiology, Matthias Schleiden Institute for Genetics, Bioinformatics and Molecular Botany Friedrich-Schiller-Universität Jena, Dornburger Str. 159, 07743 Jena, Germany.ORCID 0000-0003-2676-1505
Katharina SenkleiterFriedrich-Alexander-Universität Erlangen-Nürnberg, Department of Biology, Pharmaceutical Biology, Staudtstraße 5, 91058 Erlangen, Germany.
Harald LanigNational High Performance Computing Center (NHR@FAU), Friedrich-Alexander-Universität Erlangen-Nürnberg, Martensstraße 1, 91058 Erlangen, Germany.ORCID 0000-0003-1593-5557
Wolfgang KreisFriedrich-Alexander-Universität Erlangen-Nürnberg, Department of Biology, Pharmaceutical Biology, Staudtstraße 5, 91058 Erlangen, Germany.ORCID 0000-0002-4239-4349
Jennifer MunkertFriedrich-Alexander-Universität Erlangen-Nürnberg, Department of Biology, Pharmaceutical Biology, Staudtstraße 5, 91058 Erlangen, Germany.

Funding

Dr. Hertha and Helmut Schmauser-Stiftung xxxFAU Gender and Diversity fund x
6 · The paper itself

Abstract

Enzymes capable of processing a variety of compounds enable plants to adapt to diverse environmental conditions. PRISEs (progesterone-5β-reductase/iridoid synthase-like enzymes), examples of such substrate-promiscuous enzymes, are involved in iridoid and cardenolide pathways and demonstrate notable substrate promiscuity by reducing the activated C=C double bonds of plant-borne and exogenous 1,4-enones. In this study, we identified PRISE genes in

Indexed as

CardenolidesMutagenesis, Site-DirectedPlantagoAmino Acid SequenceIridoidsMolecular Docking SimulationOxidoreductasesPlant ProteinsProgesteroneSubstrate SpecificityCardenolidesIridoidsOxidoreductasesPlant ProteinsProgesteroneprogesterone 5 beta-reductasecardenolidesiridoid biosynthesisPlantago lanceolataPlantago mediaPRISEsprogesteronesite-directed mutagenesisstructural analysis

Identifiers

PMID39683944
PMCPMC11643720

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.