Evidence map›Paper›PMID 39683923›Full record

ArticleMolecules (Basel, Switzerland)2024

Bioactive Potential of Chitosan-Oleic Acid Nanoparticles Loaded with Lemon Peel Essential Oil for Topical Treatment of Vulvovaginal Candidiasis.

Faten M Ibrahim, Eman Samy Shalaby, Mohamed F Abdelhameed, Radwa H El-Akad, Kawkab A Ahmed, Mohamed S Abdel-Aziz, El Sayed El Habbasha, Cristina V Rodrigues, Manuela Pintado

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Faten M IbrahimMedicinal and Aromatic Plants Research Department, Pharmaceutical and Drug Industries Research Institute, National Research Centre, Cairo P.O. Box 12622, Egypt.ORCID 0000-0001-8769-9667
Eman Samy ShalabyPharmaceutical Technology Department, Pharmaceutical and Drug Industries Research Institute, National Research Centre, Cairo P.O. Box 12622, Egypt.ORCID 0000-0002-3932-2301
Mohamed F AbdelhameedPharmacology Department, Medical Research and Clinical Studies Institute, National Research Centre, Dokki, Giza P.O. Box 12622, Egypt.ORCID 0000-0001-6100-6498
Radwa H El-AkadPharmacognosy Department, Pharmaceutical and Drug Industries Research Institute, National Research Centre, Dokki, Giza P.O. Box 12622, Egypt.ORCID 0000-0003-0245-1406
Kawkab A AhmedDepartment of Pathology, Faculty of Veterinary Medicine, Cairo University, Giza P.O. Box 12211, Egypt.
Mohamed S Abdel-AzizMicrobial Chemistry Department, Biotechnology Research Institute, National Research Centre, Cairo P.O. Box 12622, Egypt.
El Sayed El HabbashaField Crops Research Department, National Research Centre, Cairo P.O. Box 12622, Egypt.ORCID 0000-0003-4126-1998
Cristina V RodriguesCBQF-Centro de Biotecnologia e Química Fina, Laboratório Associado, Escola Superior de Biotecnologia, Universidade Católica Portuguesa, Rua Diogo Botelho 1327, 4169-005 Porto, Portugal.ORCID 0000-0001-5937-2253
Manuela PintadoCBQF-Centro de Biotecnologia e Química Fina, Laboratório Associado, Escola Superior de Biotecnologia, Universidade Católica Portuguesa, Rua Diogo Botelho 1327, 4169-005 Porto, Portugal.ORCID 0000-0002-0760-3184

Funding

MEDISMART project DOI 10.54499/PRIMA/0014/2019
6 · The paper itself

Abstract

The rising incidence of vulvovaginal candidiasis (VVC) has been leading to the development of alternative antifungal therapies. This study aimed to develop a topical chitosan-oleic acid nanoparticle (CH-OA-NP) cream loaded with lemon peel essential oil (LPEO) for VVC treatment. The characterization of the optimal nanoparticle formulation (F4: 10 g/L CH, 2:1 OA/LPEO ratio) showed high encapsulation efficiency, stability, and controlled release. Moreover, it was characterized regarding its particle size, polydispersity index, zeta potential, and chemical/morphological profile. LPEO-related compounds (e.g., eriodictyol) were identified through LC-ESI-QqTOF-HRMS in the cream matrix, suggesting the preservation of LPEO potential bioactivities after formulation. In silico docking of 12 LPEO metabolites revealed that compounds such as citronellic acid exerted inhibitory effects against several inflammation-associated enzymes (e.g., 14-α-Demethylase). In vitro antimicrobial tests demonstrated remarkable activity against

Indexed as

Antifungal AgentsCandida albicansCandidiasis, VulvovaginalChitosanNanoparticlesOils, VolatileOleic AcidAdministration, TopicalAnimalsCitrusFemaleMicrobial Sensitivity TestsMolecular Docking SimulationPlant OilsRatsAntifungal AgentsChitosanlemon oilOils, VolatileOleic AcidPlant Oilsantimicrobial therapiesbioactive compoundschitosan–oleic acid nanoparticlescitrus byproductslemon essential oilmolecular dockingvulvovaginal candidiasis

Identifiers

PMID39683923
PMCPMC11643761

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.