ReviewMolecules (Basel, Switzerland)2024
Biotechnological 2-Phenylethanol Production: Recent Developments.
Review in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed.
- Fermentation Process Optimization for High 2-Phenylethanol Aroma Whisky.International journal of molecular sciences · 2026Article
- Salivary volatilome profiling in pediatric eosinophilic esophagitis: a pilot study on a non-invasive approach in clinical practice.Life medicine · 2026Article
- Systematic process optimization for enhanced biosynthesis of 2-phenylethanol using Candida sorboxylosa.Bioprocess and biosystems engineering · 2026Article
- High-titer 2-phenylethanol production in Escherichia coli via decarboxylation-step optimization and a vegetable-oil overlay for biocompatible in situ recovery.Journal of biological engineering · 2026Article
- An unfolded protein response-inducible protein (ULI1) mediates aromatic alcohols biosynthesis through reinforcing the Ehrlich pathway inFrontiers in microbiology · 2026Article
- EngineeringFrontiers in microbiology · 2026Review
- Manganese Complexes Bearing Bulky DAB Ligands as Efficient Catalysts for the Solvent-Free Hydroboration of Ketones.International journal of molecular sciences · 2025Article
- Screening of High-Yield 2-Phenylethanol Producing Strain from Wild-TypeFoods (Basel, Switzerland) · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
2-Phenylethanol (2-PE) is a key flavor compound with a rose-like scent, used in the cosmetics, perfume, home care and food industries. This aroma compound can be obtained naturally from various flowers, however chemical synthesis is the most used route to meet market demand. The increasing interest in natural products has led to the development of more environmentally friendly alternatives for 2-PE production through biotechnological approaches. The most efficient approach involves the biotransformation of L-phenylalanine into 2-PE via the Ehrlich pathway, a process observed in different microorganisms such as yeasts and bacteria. 2-PE produced by this way can be considered as natural. However, due to the toxicity of the aroma to the producing microorganism, low production yields are typically obtained, motivating efforts to develop production processes that can overcome this bottleneck, enhance 2-PE yields and reduce the production costs. This review presents and discusses the latest advances in the bioproduction of 2-PE through microbial fermentation, in terms of producing strains, the optimization of cultivation processes, strategies to mitigate product toxicity, and the use of low value feedstocks. Novel applications for 2-PE are also highlighted.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.